Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7904.017 | uM | 0.71519 | 1.03140 | -0.8732 | -0.4185 | 1.6610 | 0.6701 | 0.7944 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7906.017 | uM | 0.95890 | 1.19080 | -1.0000 | -0.9764 | 4.9984 | 0.9310 | 0.8190 | 0.3822 | |
| MDA-MB-468 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7905.035 | uM | 0.42442 | 0.83511 | -0.9999 | -1.0000 | 1.6231 | 0.9493 | 0.9298 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7907.017 | uM | 0.33988 | 0.79719 | -0.9533 | -0.9217 | 1.2258 | 0.8581 | 0.9568 | 1.4157 | |
| MDA-MB-468 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7906.016 | uM | inf | inf | 0.1315 | 0.1315 | 0.0000 | 0.2415 | 0.2554 | 0.8028 | |
| MDA-MB-468 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7909.016 | uM | 29.28930 | 33.41480 | 0.2734 | -0.4651 | 4.9905 | 0.0487 | 0.8489 | 1.3701 | |
| MDA-MB-468 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7907.016 | uM | 20.66940 | 35.50110 | 0.0938 | -0.9323 | 1.9457 | 0.0723 | 0.9286 | 1.3145 | |
| MDA-MB-468 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7905.016 | uM | 17.38570 | 21.6580 | -0.7932 | -1.0000 | 5.0000 | 0.1475 | 0.9508 | 0.6240 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7906.012 | uM | 0.00062 | 0.00321 | -0.8093 | -0.7684 | 0.5677 | 1.3829 | 0.6159 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7905.012 | uM | 0.01689 | 0.02851 | -0.7388 | -0.7974 | 1.8227 | 1.1600 | 0.9843 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7907.012 | uM | 0.02994 | 0.03704 | -0.4344 | -0.4468 | 2.9989 | 0.9026 | 0.9903 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7905.011 | uM | inf | inf | 0.0141 | 0.0141 | 0.0000 | 0.3669 | 0.5726 | 0.9066 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7906.011 | uM | 0.54237 | 0.48062 | -0.1786 | 0.2264 | 4.9880 | 0.3498 | 0.5811 | 0.7830 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7907.011 | uM | 6.74840 | 0.16136 | 0.2480 | 0.3689 | 0.3585 | 0.3209 | 0.6476 | 1.4119 | |
| MDA-MB-468 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7909.075 | uM | 0.17355 | 0.10543 | 0.3469 | 0.4586 | 4.9968 | 0.3593 | 0.9388 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7909.001 | uM | 0.02771 | 0.03019 | -0.5424 | -0.1327 | 2.7489 | 0.5962 | 0.8630 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7904.001 | uM | 0.01577 | 0.01861 | -0.5617 | -0.3088 | 2.9050 | 0.7579 | 0.9274 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7907.001 | uM | 0.01541 | 0.01787 | -0.7783 | -0.5487 | 5.0000 | 0.8713 | 0.9517 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7906.001 | uM | 0.01404 | 0.01736 | -0.9808 | -0.9456 | 5.0000 | 1.1656 | 0.9648 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7905.001 | uM | 0.01546 | 0.01879 | -0.9661 | -0.8267 | 5.0000 | 1.0408 | 0.9694 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7909.001 | uM | 0.00120 | 0.00121 | 0.2096 | -0.0127 | 5.0000 | 0.8306 | 0.6530 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7904.001 | uM | 0.00066 | 0.00071 | -0.0087 | -0.2074 | 5.0000 | 1.0124 | 0.6937 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7907.001 | uM | 0.00479 | 0.00628 | -0.3488 | -0.3455 | 1.9422 | 0.8990 | 0.8321 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7906.001 | uM | 0.00175 | 0.00460 | -0.6970 | -0.7979 | 0.9875 | 1.2579 | 0.8518 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7905.001 | uM | 0.00337 | 0.00440 | -0.8845 | -0.6726 | 3.1893 | 1.1402 | 0.9093 | 0.7433 |