Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7906.001 | uM | 0.01455 | 0.02206 | -0.9694 | -0.9295 | 2.5257 | 1.2756 | 0.7126 | 0.5685 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7905.001 | uM | 0.0120 | 0.01548 | -0.8909 | -0.9012 | 4.0535 | 1.1707 | 0.9541 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7909.001 | uM | 0.02315 | 0.03237 | -0.3314 | -0.2766 | 1.3143 | 0.6857 | 0.9582 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7904.001 | uM | 0.01403 | 0.02089 | -0.5140 | -0.4651 | 1.6519 | 0.8488 | 0.9791 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7907.001 | uM | 0.01433 | 0.02177 | -0.6962 | -0.6264 | 1.9431 | 0.9304 | 0.9878 | 1.3308 | |
| MDA-MB-468 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7906.011 | uM | inf | inf | -0.8890 | -0.8890 | 0.0000 | 0.5030 | 0.4264 | 0.7830 | |
| MDA-MB-468 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7905.011 | uM | 26.20360 | 60.71120 | -0.9301 | -1.0000 | 1.3075 | 0.5044 | 0.8388 | 0.9066 | |
| MDA-MB-468 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7907.011 | uM | 55.54990 | 143.78910 | -0.7858 | -1.0000 | 1.1551 | 0.2988 | 0.9606 | 1.4119 | |
| MDA-MB-468 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7909.075 | uM | 69.24680 | 170.64390 | -0.6756 | -1.0000 | 1.2181 | 0.2610 | 0.9688 | 1.5307 | |
| MDA-MB-468 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7904.068 | uM | inf | inf | 0.0450 | 0.0450 | 0.0000 | 0.2762 | 0.5273 | 1.3499 | |
| MDA-MB-468 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7909.068 | uM | 18.43620 | 27.9190 | -0.7176 | -0.7513 | 2.2104 | 0.3963 | 0.8281 | 1.2903 | |
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 7906.002 | uM | 0.00931 | 0.01144 | -0.8472 | -0.9052 | 4.9990 | 1.2973 | 0.7832 | 0.5736 | |
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 7905.002 | uM | 0.00606 | 0.00753 | -0.9966 | -0.9878 | 5.0000 | 1.4358 | 0.8612 | 0.4198 | |
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 7907.002 | uM | 0.00773 | 0.00920 | -0.7287 | -0.6937 | 5.0000 | 1.0953 | 0.9974 | 1.5984 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7907.043 | uM | inf | inf | 0.4187 | 0.4187 | 0.0000 | 0.1936 | 0.4690 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7904.077 | uM | 0.07480 | 0.19706 | -0.6180 | -0.3934 | 0.5992 | 0.6604 | 0.8834 | 1.5112 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7905.007 | uM | 0.00292 | 0.03439 | -0.8739 | -0.9897 | 0.4425 | 1.2300 | 0.9337 | 0.8475 | |
| MDA-MB-468 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7906.007 | uM | 0.16356 | 0.21881 | -0.6081 | -0.6811 | 2.9537 | 0.7902 | 0.9870 | 0.6194 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7906.012 | uM | inf | inf | 0.2629 | 0.2629 | 0.0000 | 0.1652 | -0.0328 | 0.4916 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7905.012 | uM | inf | inf | 0.4662 | 0.4662 | 0.0000 | 0.1098 | -0.0073 | 0.7027 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7906.036 | uM | inf | inf | -0.2550 | -0.2550 | 0.0000 | 0.3189 | 0.4182 | 0.8690 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7905.036 | uM | inf | inf | -0.4646 | -0.4646 | 0.0000 | 0.2469 | 0.5304 | 0.5385 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7907.012 | uM | inf | inf | 0.3830 | 0.3830 | 0.0000 | 0.1361 | 0.5458 | 1.3872 | |
| MDA-MB-468 | TNBC | Basal A | Trametinib | MEK | MAPK | 7909.05 | uM | 14.7430 | 17.49650 | 0.2584 | -0.6771 | 5.0000 | 0.0579 | 0.8871 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7906.018 | uM | 0.00003 | 0.00009 | -0.9241 | -0.7076 | 0.8524 | 1.6148 | 0.7919 | 0.9087 |