Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10127.001 | uM | 0.01904 | 0.01938 | -0.9787 | -0.0461 | 4.9630 | 0.5228 | 0.5961 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9759.001 | uM | 0.01929 | 0.02068 | 0.0763 | -0.1889 | 4.6086 | 0.6864 | 0.8737 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9760.001 | uM | 0.02066 | 0.02355 | -0.8539 | -0.4590 | 4.9802 | 0.7711 | 0.9251 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10127.001 | uM | 0.04062 | 0.04604 | -0.8103 | -0.4349 | 5.0000 | 0.7251 | 0.950 | 0.8568 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9759.001 | uM | 0.03930 | 0.04866 | -0.4805 | -0.5014 | 3.2511 | 0.7650 | 0.9925 | 1.1834 | |
| SK-BR-3 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9760.001 | uM | 0.05426 | 0.06827 | -0.5834 | -0.5699 | 3.3109 | 0.7358 | 0.9982 | 0.9677 | |
| SK-BR-3 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 7527.088 | uM | 57.13210 | 251.79710 | 0.6293 | -1.0000 | 0.7407 | 0.0668 | 0.8958 | 2.0430 | |
| SK-BR-3 | HER2amp | Luminal | Ibandronate | FDPS | 11851.143 | uM | 106.36960 | 92.14980 | 0.2009 | 0.0457 | 0.6683 | 0.2448 | 0.9661 | 1.4447 | ||
| SK-BR-3 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 11851.157 | uM | 8.58520 | 497.63610 | 0.2687 | -1.0000 | 0.2706 | 0.2363 | 0.9290 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 7527.093 | uM | 3.12690 | 4.88110 | -0.8372 | -0.8470 | 2.2255 | 0.3986 | 0.9975 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7526.091 | uM | 24.89690 | 38.9890 | -0.8908 | -0.9044 | 2.3025 | 0.4506 | 0.9901 | 1.6709 | |
| SK-BR-3 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7527.092 | uM | 25.47980 | 36.46430 | -0.8133 | -0.8154 | 2.6985 | 0.3973 | 0.9989 | 2.0383 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7527.067 | uM | 0.03382 | 0.03976 | -0.8582 | -0.3977 | 3.6171 | 0.7195 | 0.9306 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7526.067 | uM | 0.02294 | 0.03032 | -0.8550 | -0.5062 | 2.5073 | 0.7999 | 0.9630 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7527.095 | uM | 0.01306 | 0.01554 | -0.8800 | -0.4185 | 3.5040 | 0.8380 | 0.8918 | 1.9173 | |
| SK-BR-3 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7526.095 | uM | 0.01050 | 0.01234 | -0.9402 | -0.6194 | 5.0000 | 0.9986 | 0.9314 | 1.4693 | |
| SK-BR-3 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 11851.144 | uM | inf | inf | -0.6295 | -0.6295 | 0.0000 | 0.3314 | 0.5646 | 1.3716 | |
| SK-BR-3 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 11851.161 | uM | 21.87390 | 53.49590 | 0.0342 | -1.0000 | 1.2284 | 0.1209 | 0.9709 | 1.4516 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7526.098 | uM | 0.85332 | 1.0080 | -0.0384 | -0.1070 | 1.1643 | 0.2603 | 0.9862 | 1.5260 | |
| SK-BR-3 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7527.098 | uM | 0.20555 | 0.19482 | 0.0280 | 0.0439 | 1.7128 | 0.3362 | 0.9971 | 1.7263 | |
| SK-BR-3 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 11851.154 | uM | 0.05928 | 0.08284 | -0.9587 | -0.9633 | 3.2086 | 0.8941 | 0.9986 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11851.154 | uM | 1.16050 | 4.68250 | -0.8054 | -1.0000 | 0.7876 | 0.3691 | 0.9609 | 1.1765 | |
| SK-BR-3 | HER2amp | Luminal | Mebendazole | 12999.174 | uM | 0.31236 | 0.52676 | -0.5382 | -0.5155 | 1.3558 | 0.5746 | 0.9936 | 0.8315 | |||
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7526.084 | uM | 0.59448 | 0.11622 | 0.2513 | 0.3240 | 0.6396 | 0.4104 | 0.9418 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7527.085 | uM | 53.46920 | 0.19976 | 0.4715 | 0.4939 | 0.7888 | 0.2894 | 0.9607 | 1.9392 |