Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7907.011 | uM | 69.81870 | 101.07450 | -0.9200 | -0.9206 | 2.8226 | 0.3809 | 0.9936 | 1.4119 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7906.018 | uM | inf | inf | 0.5173 | 0.5173 | 0.0000 | 0.4359 | -0.2734 | 0.9087 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7905.018 | uM | inf | inf | 0.5870 | 0.5870 | 0.0000 | 0.1000 | -0.0447 | 0.8988 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7907.018 | uM | inf | inf | 0.6947 | 0.6947 | 0.0000 | 0.0550 | 0.3041 | 1.5217 | |
| MDA-MB-468 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7904.018 | uM | inf | inf | 0.7142 | 0.7142 | 0.0000 | 0.0177 | 0.5339 | 1.4056 | |
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7906.018 | uM | inf | inf | -0.9383 | -0.9383 | 0.0000 | 1.1311 | 0.5414 | 0.9087 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7904.018 | uM | 3.02880 | 158.54660 | -0.7754 | -1.0000 | 0.2776 | 0.6540 | 0.7761 | 1.4056 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7907.018 | uM | 1.07690 | 84.78930 | -0.8313 | -1.0000 | 0.2516 | 0.7516 | 0.8193 | 1.5217 | ||
| MDA-MB-468 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7905.018 | uM | 0.38067 | 7.8830 | -0.9896 | -1.0000 | 0.3625 | 1.0022 | 0.8830 | 0.8988 | ||
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7904.017 | uM | 3.07990 | 2.72390 | -0.2970 | 0.1683 | 3.3420 | 0.3067 | 0.7552 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7905.035 | uM | 1.8640 | 6.05840 | -0.9986 | -1.0000 | 0.9320 | 0.6896 | 0.8755 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7907.017 | uM | 6.68970 | 15.37850 | -0.9443 | -1.0000 | 1.3198 | 0.4796 | 0.9738 | 1.4157 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7906.017 | uM | 19.10690 | 23.8020 | -0.9991 | -1.0000 | 5.0000 | 0.3848 | 0.9761 | 0.3822 | |
| MDA-MB-468 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7909.13 | uM | 7.83190 | 18.76060 | -0.8399 | -0.9477 | 1.2170 | 0.4294 | 0.9802 | 1.5270 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7907.043 | uM | inf | inf | 0.8215 | 0.8215 | 0.0000 | 0.0156 | 0.4868 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7906.007 | uM | 25.89040 | 32.93250 | -0.9513 | -1.0000 | 4.5663 | 0.2969 | 0.8040 | 0.6194 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7905.007 | uM | 5.73780 | 11.48020 | -0.8858 | -0.9903 | 1.5747 | 0.4054 | 0.8993 | 0.8475 | |
| MDA-MB-468 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7904.077 | uM | 36.05070 | 90.21680 | 0.0294 | -1.0000 | 1.1977 | 0.1016 | 0.940 | 1.5112 | |
| MDA-MB-468 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7906.002 | uM | 0.00678 | 0.00831 | -0.9694 | -0.8803 | 5.0000 | 1.1978 | 0.7602 | 0.5736 | |
| MDA-MB-468 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7907.002 | uM | 0.00296 | 0.00490 | -0.5517 | -0.6130 | 1.5918 | 0.9737 | 0.9754 | 1.5984 | |
| MDA-MB-468 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7905.002 | uM | 0.00174 | 0.00309 | -0.9941 | -1.0000 | 1.9157 | 1.2558 | 0.9983 | 0.4198 | |
| MDA-MB-468 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7907.043 | uM | inf | inf | -0.1872 | -0.1872 | 0.0000 | 0.2631 | 0.3654 | 1.6330 | |
| MDA-MB-468 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7906.007 | uM | 0.24069 | 0.56815 | -0.9680 | -0.9273 | 1.2212 | 0.7840 | 0.8325 | 0.6194 | |
| MDA-MB-468 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7904.077 | uM | 0.79705 | 1.42230 | -0.7178 | -0.4825 | 1.1664 | 0.4417 | 0.9462 | 1.5112 | |
| MDA-MB-468 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7905.007 | uM | 0.47685 | 0.63965 | -0.9982 | -0.8947 | 3.4926 | 0.7855 | 0.9470 | 0.8475 |