Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7899.001 | uM | 0.13542 | 0.02455 | 0.1682 | 0.4192 | 1.0672 | 0.3091 | 0.7940 | 2.0444 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 10266.001 | uM | 0.01345 | 0.01380 | -0.1922 | -0.0242 | 1.8703 | 0.6598 | 0.8030 | 0.8138 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7900.001 | uM | 0.01148 | 0.05060 | -0.2775 | -0.3310 | 0.3425 | 0.6711 | 0.8630 | 0.7944 | |
| MDA-MB-436 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7898.001 | uM | 0.01705 | 0.01656 | -0.0566 | 0.0346 | 2.4382 | 0.5937 | 0.9091 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | LY294002 | PI3K | PI3K | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7902.075 | uM | 90.53730 | 533.29250 | -0.0929 | -1.0000 | 0.6195 | 0.2153 | 0.9315 | 1.9585 | |
| MDA-MB-436 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7898.011 | uM | 65.23630 | 222.79440 | -0.4440 | -1.0000 | 0.8945 | 0.2544 | 0.9590 | 1.0373 | |
| MDA-MB-436 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10266.011 | uM | 30.96790 | 102.12640 | -0.7782 | -1.0000 | 0.9207 | 0.3143 | 0.9797 | 0.6895 | |
| MDA-MB-436 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7900.011 | uM | 86.94260 | 106.4080 | -0.8727 | -0.8730 | 5.0000 | 0.2400 | 0.9959 | 0.5977 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0820 | 0.0614 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | PD184352 | MEK | MAPK | 7898.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0820 | 0.0614 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7899.068 | uM | inf | inf | 0.3480 | 0.3480 | 0.0000 | 0.2228 | 0.3774 | 1.9316 | |
| MDA-MB-436 | TNBC | Basal B | Taxol | TUBB | TUBB | 10266.002 | uM | 0.01263 | 0.02198 | -0.6138 | -0.3854 | 1.0308 | 0.7789 | 0.9445 | 0.6757 | |
| MDA-MB-436 | TNBC | Basal B | Taxol | TUBB | TUBB | 7900.002 | uM | 0.05337 | 0.05943 | -0.4792 | -0.3560 | 4.9999 | 0.6534 | 0.9479 | 0.4748 | |
| MDA-MB-436 | TNBC | Basal B | Taxol | TUBB | TUBB | 7898.002 | uM | 0.03169 | 0.03472 | -0.2253 | -0.1630 | 3.0900 | 0.6203 | 0.9950 | 1.1328 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7899.077 | uM | 0.03068 | 0.02655 | -0.2010 | 0.0442 | 0.6406 | 0.5943 | 0.8838 | 2.1925 | |
| MDA-MB-436 | TNBC | Basal B | Topotecan | TOP1 | TOP | 10266.121 | uM | 0.02557 | 0.02937 | -0.7058 | -0.4997 | 4.9983 | 1.0020 | 0.9380 | 0.7110 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 7900.012 | uM | inf | inf | 0.4439 | 0.4439 | 0.0000 | 0.5210 | -0.1349 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 7900.036 | uM | inf | inf | 0.1830 | 0.1830 | 0.0000 | 0.2760 | 0.0114 | 0.7997 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 7902.05 | uM | inf | inf | 0.6492 | 0.6492 | 0.0000 | 0.1023 | 0.0604 | 1.8149 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 10266.024 | uM | inf | inf | 0.1069 | 0.1069 | 0.0000 | 0.1775 | 0.4772 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Trametinib | MEK | MAPK | 7898.036 | uM | inf | inf | 0.4847 | 0.4847 | 0.0000 | 0.1320 | 0.5322 | 1.1276 | |
| MDA-MB-436 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 10266.026 | uM | inf | inf | 0.0817 | 0.0817 | 0.0000 | 0.1773 | 0.3932 | 0.6682 | |
| MDA-MB-436 | TNBC | Basal B | U-0126 | MEK | MAPK | 7898.029 | uM | inf | inf | 0.8073 | 0.8073 | 0.0000 | 0.0952 | -0.0166 | 0.7130 | |
| MDA-MB-436 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7900.018 | uM | 0.00034 | 0.00766 | -0.9981 | -0.8167 | 0.3116 | 1.1293 | 0.8603 | 0.8304 |