Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7517.065 | uM | 34.41720 | 51.60290 | -0.8776 | -0.8769 | 2.5010 | 0.8871 | 0.9967 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7518.065 | uM | 39.63220 | 59.15820 | -0.8703 | -0.8411 | 2.4631 | 0.8032 | 0.9986 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | XRP44X | ELK3 | MAPK | 12414.157 | uM | 0.96405 | 0.99703 | -0.4029 | -0.0916 | 5.0000 | 0.4931 | 0.7841 | 1.0392 | |
| MDA-MB-453 | TNBC | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14646.189 | uM | 0.53402 | 0.89486 | -0.8450 | -0.8042 | 1.8572 | 0.6775 | 0.9739 | 1.0620 | |
| MDA-MB-453 | TNBC | Luminal | ZM-447439 | AURK | AURK | 12414.169 | uM | inf | 0.65065 | 0.5105 | 0.5416 | 2.2587 | 0.1874 | 0.8611 | 1.1235 | |
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7906.016 | uM | inf | inf | -0.6451 | -0.6451 | 0.0000 | 0.5855 | 0.2634 | 0.8028 | ||
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7907.016 | uM | inf | inf | 0.5786 | 0.5786 | 0.0000 | 0.1202 | 0.4906 | 1.3145 | ||
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7909.016 | uM | 108.46670 | 254.11780 | 0.2570 | -1.0000 | 1.2904 | 0.1317 | 0.6828 | 1.3701 | ||
| MDA-MB-468 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7905.016 | uM | 1.04560 | 9.77180 | -0.9264 | -1.0000 | 0.4916 | 0.5676 | 0.6993 | 0.6240 | ||
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7906.037 | uM | inf | inf | -0.9658 | -0.9658 | 0.0000 | 0.8427 | 0.5316 | 0.7972 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7909.05 | uM | 2.82850 | 3.21440 | -0.6971 | -0.4476 | 4.9993 | 0.3909 | 0.9512 | 1.1429 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7907.037 | uM | 1.48170 | 1.8630 | -0.7647 | -0.5216 | 3.1206 | 0.4662 | 0.9611 | 1.3673 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7905.037 | uM | 0.86819 | 1.05230 | -0.9966 | -0.8080 | 5.0000 | 0.6312 | 0.9702 | 0.6714 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7905.035 | uM | 84.42930 | 244.40530 | -0.8385 | -0.8600 | 0.9414 | 0.6954 | 0.9407 | 0.8588 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7909.13 | uM | 296.96450 | 411.31820 | -0.3300 | -0.2753 | 1.3467 | 0.3890 | 0.9663 | 1.5270 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7907.017 | uM | 127.80370 | 331.63740 | -0.5890 | -0.5993 | 0.8262 | 0.5160 | 0.9824 | 1.4157 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7904.017 | uM | 189.18420 | 283.16380 | -0.2286 | -0.2563 | 1.0261 | 0.4171 | 0.9852 | 1.4023 | |
| MDA-MB-468 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7906.017 | uM | 470.6870 | 581.98590 | -0.9702 | -0.9450 | 5.0000 | 0.5412 | 0.9967 | 0.3822 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7907.016 | uM | inf | inf | 0.6764 | 0.6764 | 0.0000 | 0.0643 | 0.0143 | 1.3145 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7905.016 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0810 | 0.0466 | 0.6240 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7906.016 | uM | inf | inf | -0.3786 | -0.3786 | 0.0000 | 0.4066 | 0.1642 | 0.8028 | |
| MDA-MB-468 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7909.016 | uM | 28.27810 | 33.14810 | -0.6061 | -0.6066 | 5.0000 | 0.1979 | 0.9864 | 1.3701 | |
| MDA-MB-468 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7906.011 | uM | 45.30540 | 56.2330 | -0.9880 | -0.9727 | 4.9994 | 0.6715 | 0.6186 | 0.7830 | |
| MDA-MB-468 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7905.011 | uM | 33.21210 | 54.79770 | -0.9933 | -1.0000 | 2.1940 | 0.5765 | 0.9589 | 0.9066 | |
| MDA-MB-468 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7909.075 | uM | 53.80210 | 93.07010 | -0.8926 | -0.9070 | 1.8879 | 0.4088 | 0.9887 | 1.5307 |