Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7912.05 | uM | 0.01034 | 0.0180 | -0.9357 | -0.6561 | 1.5123 | 1.1090 | 0.9677 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 11851.143 | uM | 190.23640 | 1000.00000 | 0.0454 | -0.3391 | 0.3120 | 0.3186 | 0.9235 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9760.131 | uM | 18.3860 | 1000.00000 | -0.4736 | -0.9151 | 0.2603 | 0.6203 | 0.8050 | 0.9878 | |
| SK-BR-3 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 11851.158 | uM | 0.01414 | 0.02468 | -0.9334 | -0.6364 | 1.4731 | 1.0048 | 0.9340 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7527.066 | uM | inf | 6.36410 | 0.8872 | 0.8872 | 4.9991 | 0.0109 | 0.6541 | 1.9970 | |
| SK-BR-3 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7526.066 | uM | 165.54090 | 435.63610 | 0.8376 | -0.6562 | 0.8664 | 0.0138 | 0.850 | 1.5937 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 9759.019 | uM | 2.22660 | 1.73360 | 0.1080 | 0.3570 | 5.0000 | 0.2242 | 0.6620 | 1.3677 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7912.016 | uM | 0.27480 | 1.52620 | -0.8938 | -1.0000 | 0.6408 | 0.7721 | 0.9441 | 0.4337 | |
| SK-BR-3 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7914.016 | uM | 4.37920 | 7.32360 | -0.6178 | -0.6625 | 1.6407 | 0.4673 | 0.9813 | 1.6240 | |
| SK-BR-3 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 11851.158 | uM | 55.93890 | 999.99540 | 0.4556 | -0.7024 | 0.3043 | 0.1531 | 0.9055 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 7527.072 | uM | 147.98490 | 771.78830 | 0.4664 | -1.0000 | 0.6652 | 0.0848 | 0.9783 | 1.9274 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7527.074 | uM | 0.03327 | 0.04183 | -0.4074 | -0.3460 | 2.2976 | 0.8597 | 0.9892 | 1.9162 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7527.074 | uM | 0.03327 | 0.04183 | -0.4074 | -0.3460 | 2.2976 | 0.8597 | 0.9892 | 1.9162 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7526.074 | uM | 0.10468 | 0.13594 | -0.6041 | -0.5645 | 2.8914 | 0.8678 | 0.9980 | 1.6506 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7526.074 | uM | 0.10468 | 0.13594 | -0.6041 | -0.5645 | 2.8914 | 0.8678 | 0.9980 | 1.6506 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| SK-BR-3 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 15327.203 | uM | 0.00180 | 0.00383 | -0.8066 | -0.7982 | 1.2648 | 1.3619 | 0.9992 | 0.9247 | |
| SK-BR-3 | HER2amp | Luminal | Bosutinib | Src | nRTK | 11851.145 | uM | 4.40540 | 18.10430 | -0.6283 | -1.0000 | 0.7773 | 0.3574 | 0.9833 | 1.4873 | |
| SK-BR-3 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9759.011 | uM | 9.95620 | 20.98690 | -0.8893 | -0.8616 | 1.3435 | 0.6033 | 0.9950 | 1.2153 | |
| SK-BR-3 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9760.011 | uM | 15.86620 | 25.00860 | -0.9570 | -0.9407 | 2.3257 | 0.5895 | 0.9972 | 0.9634 | |
| SK-BR-3 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10127.12 | uM | 9.17670 | 11.4020 | -0.9992 | -0.9806 | 4.9999 | 0.7035 | 0.9982 | 0.5076 | |
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9760.026 | uM | inf | inf | 0.9461 | 0.9461 | 0.0000 | -0.0228 | -0.0698 | 1.0724 | |
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10127.123 | uM | inf | inf | 0.7010 | 0.7010 | 0.0000 | 0.1340 | 0.0237 | 0.8767 | |
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9759.006 | uM | inf | inf | 0.9596 | 0.9596 | 0.0000 | 0.0960 | 0.0987 | 1.2714 | |
| SK-BR-3 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7912.018 | uM | inf | inf | 0.7166 | 0.7166 | 0.0000 | 0.1633 | 0.1632 | 0.7203 |