Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | QNZ | NFkB | NFKB | 7531.096 | uM | inf | 999.01730 | 0.7706 | 0.1998 | 0.3426 | 0.0446 | 0.6665 | 3.5504 | |
| SUM159PT | TNBC | Basal B | Ribavirin | 15402.211 | uM | 51.66870 | 999.82030 | 0.4628 | -0.6950 | 0.2941 | 0.1569 | 0.8782 | 3.0887 | |||
| SUM159PT | TNBC | Basal B | Ro 32-0432 | PKC | PKC | 10520.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0236 | -0.3274 | 3.1766 | |
| SUM159PT | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 11057.144 | uM | 22.69590 | 50.71310 | -0.4344 | -1.0000 | 1.3664 | 0.1434 | 0.9948 | 3.7784 | |
| SUM159PT | TNBC | Basal B | Selumetinib | MEK | MAPK | 11057.155 | uM | 54.25520 | 19.05870 | 0.4787 | 0.0885 | 0.1862 | 0.2584 | 0.9646 | 4.1614 | |
| SUM159PT | TNBC | Basal B | Sigma A6730 | AKT | AKT | 10520.141 | uM | 11.09120 | 20.90010 | -0.7115 | -0.9538 | 1.6846 | 0.2015 | 0.9952 | 3.6374 | |
| SUM159PT | TNBC | Basal B | Sigma A6730 | AKT | AKT | 11057.158 | uM | 11.04450 | 21.67290 | -0.7343 | -1.0000 | 1.6297 | 0.2053 | 0.9975 | 3.8594 | |
| SUM159PT | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7920.068 | uM | 4.68180 | 9.92620 | -0.2346 | -0.1745 | 0.3983 | 0.3470 | 0.6243 | 4.3418 | |
| SUM159PT | TNBC | Basal B | Sirolimus | MTOR | MTOR | 9042.068 | uM | 0.13193 | 17.36430 | -0.7962 | -1.0000 | 0.2251 | 0.6042 | 0.6577 | 1.8008 | |
| SUM159PT | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7531.085 | uM | 36.49060 | 81.30910 | -0.7688 | -1.0000 | 1.3712 | 0.2215 | 0.9964 | 3.5188 | |
| SUM159PT | TNBC | Basal B | Sulindac sulfide | COX1/2 | COX | 10520.136 | uM | inf | inf | 0.9767 | 0.9767 | 0.0000 | -0.0015 | 0.0597 | 4.0331 | |
| SUM159PT | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7531.067 | uM | 2.42180 | 5.2160 | -0.7605 | -0.8093 | 1.2547 | 0.5048 | 0.9969 | 3.6061 | |
| SUM159PT | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7531.096 | uM | inf | inf | 0.8694 | 0.8694 | 0.0000 | 0.0391 | 0.3982 | 3.5504 | ||
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 9844.002 | uM | 0.01006 | 0.01523 | -0.6394 | -0.3874 | 1.3823 | 0.8015 | 0.9661 | 2.4608 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 7918.002 | uM | 0.02071 | 0.02464 | -0.2669 | -0.2406 | 2.2605 | 0.7152 | 0.9912 | 2.8377 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 13054.002 | uM | 0.00389 | 0.00463 | -0.1850 | -0.1586 | 1.5931 | 0.8001 | 0.9981 | 3.0574 | |
| SUM159PT | TNBC | Basal B | Taxol | TUBB | TUBB | 13004.002 | uM | 0.00449 | 0.00513 | -0.1960 | -0.1508 | 1.9936 | 0.7840 | 0.9981 | 3.1387 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 10520.14 | uM | 0.48877 | 0.61898 | -0.3612 | -0.3328 | 2.1599 | 0.4285 | 0.9923 | 3.7031 | |
| SUM159PT | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 11057.152 | uM | 1.15310 | 1.13690 | 0.0039 | 0.0251 | 3.6451 | 0.2485 | 0.9981 | 3.8541 | |
| SUM159PT | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 10520.135 | uM | 97.22130 | 40.41170 | 0.4897 | 0.4856 | 4.0427 | 0.0293 | 0.9568 | 3.6895 | |
| SUM159PT | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 11057.135 | uM | inf | 30.93790 | 0.6673 | 0.6670 | 4.9977 | 0.0270 | 0.9663 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 11057.144 | uM | 3.51290 | 26.67560 | -0.7417 | -1.0000 | 0.5419 | 0.4064 | 0.8413 | 3.7784 | |
| SUM159PT | TNBC | Basal B | Topotecan | TOP1 | TOP | 7918.007 | uM | 0.04050 | 0.03894 | -0.4639 | 0.0892 | 4.9965 | 0.5953 | 0.6077 | 2.9756 | |
| SUM159PT | TNBC | Basal B | Topotecan | TOP1 | TOP | 7919.043 | uM | 4.94050 | 67.03450 | -0.1227 | -1.0000 | 0.4213 | 0.2990 | 0.9850 | 3.1744 | |
| SUM159PT | TNBC | Basal B | Torkinib | 15402.211 | uM | 0.01202 | 0.01610 | -0.0537 | -0.0724 | 0.4628 | 0.6556 | 0.9950 | 3.0887 |