Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
SUM149PT
TNBC
Basal B
 Oxamflatin
HDAC
HDAC
10819.147
uM
1.1580
2.34310
 -0.8406 -0.8846 1.4453 0.5114
0.9974
 2.1652
SUM149PT
TNBC
Basal B
 Oxamflatin
HDAC
HDAC
11937.147
uM
0.46519
1.15240
 -0.7260 -0.7835 1.0392 0.5685
0.9981
 2.3986
SUM149PT
TNBC
Basal B
 PD 98059
MEK
MAPK
10819.152
uM
inf
259.810
 0.7651 0.1854 0.5497 0.0467
0.9023
 2.0116
SUM149PT
TNBC
Basal B
 PD 98059
MEK
MAPK
11937.159
uM
inf
6.93180
 0.5433 0.5270 1.3734 0.1027
0.9828
 2.2200
SUM149PT
TNBC
Basal B
 PD173074
FGFR1/3
RTK
7530.093
uM
8.44560
9.68930
 -0.3620 -0.3712 4.0415 0.0976
0.9969
 2.1548
SUM149PT
TNBC
Basal B
 PD184352
MEK
MAPK
11937.155
uM
41.57880
999.69990
 0.4428 -0.6451 0.2606 0.1663
0.8536
 2.4784
SUM149PT
TNBC
Basal B
 PD184352
MEK
MAPK
11937.155
uM
41.57880
999.69990
 0.4428 -0.6451 0.2606 0.1663
0.8536
 2.4784
SUM149PT
TNBC
Basal B
 PD184352
MEK
MAPK
10819.155
uM
21.17510
201.82950
 0.4089 -0.9984 0.4868 0.1052
0.9319
 2.0561
SUM149PT
TNBC
Basal B
 PD184352
MEK
MAPK
10819.155
uM
21.17510
201.82950
 0.4089 -0.9984 0.4868 0.1052
0.9319
 2.0561
SUM149PT
TNBC
Basal B
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7530.095
uM
inf
12.66330
 0.8180 0.8361 0.4729 0.0655
0.8273
 2.2670
SUM149PT
TNBC
Basal B
 PS-1145
IKK
NFKB
7530.065
uM
inf
inf
 0.9426 0.9426 0.0000 0.0488
0.0000
 2.0424
SUM149PT
TNBC
Basal B
 Purvalanol A
CDK1
CDK
7530.067
uM
12.6640
14.92770
 -0.2602 -0.2629 2.5691 0.2388
0.9992
 2.0748
SUM149PT
TNBC
Basal B
 QNZ
NFkB
NFKB
7530.096
uM
11.12290
30.39910
 -0.0790 -1.0000 1.0927 0.1967
0.8603
 2.1549
SUM149PT
TNBC
Basal B
 Ribavirin
15357.211
uM
162.96770
19.77270
 0.5934 0.4610 1.2092 0.0712
0.9188
 1.9588
SUM149PT
TNBC
Basal B
 SB-3CT
MMP2/9
MMP
10819.144
uM
inf
inf
 0.8022 0.8022 0.0000 0.0792
0.5064
 2.2343
SUM149PT
TNBC
Basal B
 SB-3CT
MMP2/9
MMP
11937.144
uM
43.63240
38.8480
 0.2522 0.0836 1.5754 0.0872
0.9831
 2.4293
SUM149PT
TNBC
Basal B
 Selumetinib
MEK
MAPK
11937.155
uM
1.61220
0.59332
 0.2878 0.1874 0.4699 0.2976
0.9875
 2.4784
SUM149PT
TNBC
Basal B
 Selumetinib
MEK
MAPK
10819.155
uM
0.67011
0.75359
 0.0329 -0.0415 0.6795 0.3453
0.9928
 2.0561
SUM149PT
TNBC
Basal B
 Sigma A6730
AKT
AKT
11937.158
uM
9.86460
17.01240
 -0.9092 -1.0000 2.0159 0.2431
0.9949
 2.2386
SUM149PT
TNBC
Basal B
 Sigma A6730
AKT
AKT
10819.153
uM
12.47670
22.51760
 -0.4057 -0.6907 1.4696 0.1734
0.9976
 2.0690
SUM149PT
TNBC
Basal B
 Sirolimus
MTOR
MTOR
7917.068
uM
9.11830
11.66960
 -0.6188 -0.6239 3.2831 0.4018
0.9742
 2.9241
SUM149PT
TNBC
Basal B
 Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
7530.085
uM
19.95870
55.25310
 -0.8065 -1.0000 1.0789 0.2905
0.9874
 2.1343
SUM149PT
TNBC
Basal B
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7530.067
uM
3.08050
5.95540
 -0.8631 -0.9013 1.5633 0.4944
0.9984
 2.0748
SUM149PT
TNBC
Basal B
 TAPI-0
TACE/Collagenase
7530.096
uM
inf
5.66910
 0.6982 0.6647 1.2142 0.0630
0.8442
 2.1549
SUM149PT
TNBC
Basal B
 Taxol
TUBB
TUBB
9830.002
uM
0.00867
0.00909
 -0.1990 -0.1346 4.9998 0.7185
0.9873
 1.9252