Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
SUM149PT
TNBC
Basal B
 Methotrexate
DHFR
Metabolism
7530.085
uM
inf
inf
 0.9031 0.9031 0.0000 0.0618
0.3530
 2.1343
SUM149PT
TNBC
Basal B
 Methylglyoxal
13123.184
uM
176.0360
328.64830
 -1.0000 -1.0000 1.7598 0.9086
0.9096
 0.6208
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
14284.189
uM
0.15156
0.16910
 -0.9935 -0.3646 5.0000 0.7080
0.5936
 1.3873
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
14284.189
uM
0.15156
0.16910
 -0.9935 -0.3646 5.0000 0.7080
0.5936
 1.3873
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
10819.145
uM
0.20433
0.28104
 -0.7962 -0.7809 2.9513 0.7793
0.9984
 2.1971
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
10819.145
uM
0.20433
0.28104
 -0.7962 -0.7809 2.9513 0.7793
0.9984
 2.1971
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
11937.145
uM
0.12851
0.18684
 -0.8017 -0.7761 2.5035 0.8112
0.9989
 2.3618
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
11937.145
uM
0.12851
0.18684
 -0.8017 -0.7761 2.5035 0.8112
0.9989
 2.3618
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
14652.189
uM
0.50417
0.60504
 -0.7406 -0.7440 4.9981 0.6337
0.9993
 2.3317
SUM149PT
TNBC
Basal B
 MG-132
Proteasome
Proteasome
14652.189
uM
0.50417
0.60504
 -0.7406 -0.7440 4.9981 0.6337
0.9993
 2.3317
SUM149PT
TNBC
Basal B
 Pevonedistat
NAE1
NAE1
10819.148
uM
0.19664
0.54458
 -0.5630 -0.5771 0.7534 0.5936
0.9971
 2.0950
SUM149PT
TNBC
Basal B
 Pevonedistat
NAE1
NAE1
11937.135
uM
0.30495
0.65928
 -0.5423 -0.5346 0.9431 0.5579
0.9977
 2.4451
SUM149PT
TNBC
Basal B
 Nelfinavir
13123.174
uM
8.96890
11.1730
 -0.9926 -1.0000 4.9996 0.1236
0.9954
 1.0408
SUM149PT
TNBC
Basal B
 Nilotinib
ABL
nRTK
10819.145
uM
inf
inf
 0.9866 0.9866 0.0000 0.0162
0.0826
 2.1971
SUM149PT
TNBC
Basal B
 Nilotinib
ABL
nRTK
11937.145
uM
inf
4.11650
 0.3437 0.5076 5.0000 0.1330
0.8840
 2.3618
SUM149PT
TNBC
Basal B
 NSC 663284
CDC25
CDC
10819.152
uM
2.21710
3.43830
 -0.8698 -0.8529 2.2686 0.5471
0.9988
 2.0116
SUM149PT
TNBC
Basal B
 NSC 663284
CDC25
CDC
11937.159
uM
1.99530
2.88610
 -0.8038 -0.7919 2.5716 0.5538
0.9994
 2.2200
SUM149PT
TNBC
Basal B
 NU6102
CDK1/2
CDK
11937.147
uM
9.1390
19.44930
 -0.8275 -1.0000 1.4546 0.2674
0.9612
 2.3986
SUM149PT
TNBC
Basal B
 NU6102
CDK1/2
CDK
10819.147
uM
14.89120
27.12560
 -0.6948 -1.0000 1.8319 0.2140
0.9808
 2.1652
SUM149PT
TNBC
Basal B
 Nutlin 3a
MDM2
MDM2
7530.066
uM
28.75490
52.31790
 -0.2200 -0.9999 1.8354 0.0999
0.9942
 1.9710
SUM149PT
TNBC
Basal B
 Olomoucine II
CDK1
CDK
10819.147
uM
7.07230
8.84820
 -0.7606 -0.7610 4.1293 0.3660
0.9985
 2.1652
SUM149PT
TNBC
Basal B
 Olomoucine II
CDK1
CDK
11937.147
uM
6.15360
8.92730
 -0.7378 -0.7441 2.4499 0.3599
0.9988
 2.3986
SUM149PT
TNBC
Basal B
 Omipalisib
PI3K
PI3K
7530.086
uM
0.05061
0.74814
 -0.6542 -1.0000 0.4079 0.6624
0.9914
 2.2038
SUM149PT
TNBC
Basal B
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9830.011
uM
2.28770
13.62990
 -0.7766 -1.0000 0.6156 0.6196
0.9792
 2.0792
SUM149PT
TNBC
Basal B
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7917.075
uM
3.84690
17.5680
 -0.7220 -0.9422 0.6975 0.5715
0.9862
 3.0479