Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10520.138 | uM | 1.05950 | 2.58470 | -0.2239 | -0.2988 | 0.5254 | 0.3709 | 0.9347 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11057.15 | uM | 2.65110 | 41.24140 | 0.0213 | -0.9986 | 0.4000 | 0.2444 | 0.9757 | 4.0042 | |
| SUM159PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 10520.1 | uM | 3.76560 | 2.10880 | 0.1909 | 0.2322 | 1.0771 | 0.2405 | 0.9865 | 3.6151 | |
| SUM159PT | TNBC | Basal B | TPCA-1 | IKK | NFKB | 7531.093 | uM | 5.21320 | 2.22940 | 0.3720 | 0.3580 | 1.4820 | 0.1833 | 0.9937 | 3.5995 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7918.012 | uM | 0.49909 | 0.03458 | 0.2353 | 0.3172 | 0.3770 | 0.3151 | 0.8166 | 2.9753 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9042.05 | uM | inf | 0.00489 | 0.5173 | 0.4903 | 0.2989 | 0.3056 | 0.8755 | 3.1161 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7918.036 | uM | 0.01580 | 0.00306 | 0.3431 | 0.4270 | 1.1708 | 0.3660 | 0.9286 | 2.9113 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7920.05 | uM | inf | 0.02034 | 0.4715 | 0.5077 | 0.6584 | 0.2518 | 0.9823 | 4.1624 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 9844.012 | uM | 0.00867 | 0.00452 | 0.2050 | 0.2849 | 1.2949 | 0.4496 | 0.9866 | 2.2776 | |
| SUM159PT | TNBC | Basal B | Trametinib | MEK | MAPK | 7919.036 | uM | 0.38794 | 0.00606 | 0.4640 | 0.4828 | 0.8106 | 0.3207 | 0.9910 | 3.6233 | |
| SUM159PT | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7531.065 | uM | 9.71890 | 20.70140 | -0.7758 | -0.7101 | 1.1689 | 0.7082 | 0.9953 | 3.4461 | |
| SUM159PT | TNBC | Basal B | Triciribine | AKT | AKT | 7531.074 | uM | 16.1980 | 565.3870 | 0.3865 | -1.0000 | 0.3092 | 0.1728 | 0.9805 | 3.2488 | |
| SUM159PT | TNBC | Basal B | Valproic acid | HDAC | HDAC | 11057.143 | uM | 761.54820 | 1000.00000 | -0.5710 | -0.1965 | 1.2168 | 0.2071 | 0.8155 | 4.1426 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7920.018 | uM | 0.01993 | 0.02096 | -0.2847 | -0.0483 | 1.8288 | 0.6036 | 0.9631 | 4.3723 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7918.018 | uM | 0.00074 | 0.00109 | -0.5523 | -0.3456 | 1.3735 | 1.1044 | 0.9653 | 3.0213 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7919.042 | uM | 0.01028 | 0.01106 | -0.3868 | -0.1639 | 3.8975 | 0.7505 | 0.9702 | 3.7203 | |
| SUM159PT | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 9042.018 | uM | 0.01354 | 0.01480 | -0.3788 | -0.2806 | 4.9965 | 0.8200 | 0.9845 | 3.2484 | |
| SUM159PT | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7531.065 | uM | 212.60980 | 402.07490 | -0.5230 | -0.5093 | 1.1024 | 0.4531 | 0.9895 | 3.4461 | |
| SUM159PT | TNBC | Basal B | XRP44X | ELK3 | MAPK | 11057.151 | uM | 0.93403 | 0.78279 | 0.1565 | 0.2344 | 3.5803 | 0.3103 | 0.9477 | 4.1698 | |
| SUM159PT | TNBC | Basal B | XRP44X | ELK3 | MAPK | 10520.139 | uM | 0.65397 | 0.97317 | -0.7104 | -0.4568 | 1.6327 | 0.5670 | 0.9512 | 3.6491 | |
| SUM159PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14176.189 | uM | 0.20626 | 0.25694 | -0.9999 | -0.9999 | 4.9998 | 0.8974 | 0.9827 | 0.4285 | |
| SUM159PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14625.189 | uM | 0.14414 | 0.20103 | -0.6949 | -0.7225 | 2.6877 | 0.7656 | 0.9956 | 2.7202 | |
| SUM159PT | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14287.189 | uM | 0.26273 | 0.36075 | -0.9166 | -0.8994 | 3.2460 | 0.8008 | 0.9976 | 2.3947 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 10520.138 | uM | 2.50290 | 0.69273 | 0.2033 | 0.4113 | 1.3463 | 0.2226 | 0.8598 | 3.3183 | |
| SUM159PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 11057.15 | uM | inf | 0.43340 | 0.6315 | 0.6227 | 5.0000 | 0.1138 | 0.9875 | 4.0042 |