Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 10644.146 | uM | 6.09890 | 9.03380 | -0.6534 | -0.6758 | 2.1767 | 0.3395 | 0.9581 | 0.5967 | |
| MX1 | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7523.095 | uM | inf | 0.22243 | 0.4987 | 0.5629 | 2.6377 | 0.3218 | 0.9364 | 0.8203 | |
| MX1 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7523.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0407 | -9.0127 | 0.7668 | |
| MX1 | Unknown | Unknown | Purvalanol A | CDK1 | CDK | 7523.067 | uM | inf | inf | 0.8338 | 0.8338 | 0.0000 | 0.0997 | 0.0000 | 0.8380 | |
| MX1 | Unknown | Unknown | Ro 32-0432 | PKC | PKC | 10644.142 | uM | inf | inf | 0.8577 | 0.8577 | 0.0000 | 0.0773 | -0.0086 | 0.5163 | |
| MX1 | Unknown | Unknown | SB-3CT | MMP2/9 | MMP | 12220.144 | uM | 0.21073 | 1.6780 | -0.9996 | -1.0000 | 0.5295 | 0.7991 | 0.7647 | 0.5126 | |
| MX1 | Unknown | Unknown | SB-3CT | MMP2/9 | MMP | 10644.144 | uM | 13.42830 | 26.81710 | -0.8221 | -1.0000 | 1.5883 | 0.2830 | 0.9641 | 0.5357 | |
| MX1 | Unknown | Unknown | SB-3CT | MMP2/9 | MMP | 10874.144 | uM | 16.8960 | 25.00610 | -0.9824 | -1.0000 | 2.8023 | 0.2025 | 0.9954 | 0.7282 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 12220.155 | uM | 0.02993 | 0.55898 | -0.6163 | -1.0000 | 0.3753 | 0.7675 | 0.9750 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 10874.155 | uM | 0.39717 | 0.94112 | -0.4198 | -0.4296 | 0.7188 | 0.4271 | 0.9765 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 10644.146 | uM | 0.60435 | 1.87970 | -0.9223 | -1.0000 | 0.9682 | 0.5608 | 0.9829 | 0.5967 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 10874.153 | uM | 4.18450 | 7.94640 | -0.9715 | -1.0000 | 1.7130 | 0.4452 | 0.9518 | 0.8467 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 12220.158 | uM | 1.68540 | 3.56750 | -0.9998 | -1.0000 | 1.4651 | 0.4749 | 0.9683 | 0.4308 | |
| MX1 | Unknown | Unknown | Sigma A6730 | AKT | AKT | 10644.141 | uM | 3.1030 | 4.14240 | -1.0000 | -0.9981 | 3.7981 | 0.3955 | 0.9970 | 0.4530 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 7523.069 | uM | 1.62940 | 997.53050 | 0.1017 | -0.9381 | 0.1646 | 0.3406 | 0.6845 | 0.9585 | |
| MX1 | Unknown | Unknown | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7523.084 | uM | 10.90370 | 54.52310 | -0.2511 | -0.5904 | 0.4844 | 0.4407 | 0.9634 | 0.9069 | |
| MX1 | Unknown | Unknown | Sulindac sulfide | COX1/2 | COX | 10644.136 | uM | 46.36640 | 59.40490 | -0.7288 | -0.8049 | 3.8711 | 0.1583 | 0.9517 | 0.5562 | |
| MX1 | Unknown | Unknown | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7523.067 | uM | 5.74720 | 8.93030 | -0.9946 | -1.0000 | 2.4926 | 0.5726 | 0.9637 | 0.8380 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 12220.159 | uM | 0.20776 | 0.27858 | -0.9963 | -0.9811 | 3.7022 | 0.7524 | 0.9910 | 0.4788 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 10644.14 | uM | 0.13263 | 0.16522 | -1.0000 | -0.9999 | 5.0000 | 0.8599 | 0.9930 | 0.4302 | |
| MX1 | Unknown | Unknown | TCS 2312 | CHK1 | CHK | 10874.152 | uM | 0.27737 | 0.39354 | -0.9901 | -0.9884 | 3.1183 | 0.6472 | 0.9985 | 0.7706 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 10644.135 | uM | inf | inf | 0.0909 | 0.0909 | 0.0000 | 0.3654 | 0.3187 | 0.5273 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 10874.148 | uM | inf | inf | 0.4360 | 0.4360 | 0.0000 | 0.0768 | 0.3334 | 0.6972 | |
| MX1 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 12220.135 | uM | inf | inf | 0.2711 | 0.2711 | 0.0000 | 0.3676 | 0.4487 | 0.6564 | |
| MX1 | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 12220.144 | uM | 0.02360 | 0.77539 | -0.9859 | -1.0000 | 0.3146 | 0.8616 | 0.8928 | 0.5126 |