Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-175-VII
HR+
Luminal
 NSC 663284
CDC25
CDC
12126.159
uM
6.71340
9.33720
 -0.9931 -1.0000 3.3302 0.5902
0.9340
 0.7389
MDA-MB-175-VII
HR+
Luminal
 NSC 663284
CDC25
CDC
10818.152
uM
4.34820
7.25220
 -0.9998 -1.0000 2.1476 0.5844
0.9767
 0.4535
MDA-MB-175-VII
HR+
Luminal
 NU6102
CDK1/2
CDK
12126.147
uM
inf
inf
 -0.2083 -0.2083 0.0000 0.2998
0.4880
 0.7140
MDA-MB-175-VII
HR+
Luminal
 NU6102
CDK1/2
CDK
10818.147
uM
48.72710
60.59660
 -0.2276 -0.9872 5.0000 0.1847
0.8575
 0.5138
MDA-MB-175-VII
HR+
Luminal
 NU6102
CDK1/2
CDK
10642.147
uM
64.52010
69.88760
 0.4495 -0.2437 4.9685 0.0481
0.9289
 0.6592
MDA-MB-175-VII
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7499.066
uM
4.60090
31.94820
 -0.1899 -1.0000 0.5669 0.3015
0.9338
 0.7917
MDA-MB-175-VII
HR+
Luminal
 Nutlin 3a
MDM2
MDM2
7500.066
uM
10.30060
40.86250
 -0.2280 -1.0000 0.7973 0.1855
0.9525
 0.7802
MDA-MB-175-VII
HR+
Luminal
 Olomoucine II
CDK1
CDK
10818.147
uM
3.38190
4.17960
 -0.1854 -0.1806 1.4560 0.4109
0.9053
 0.5138
MDA-MB-175-VII
HR+
Luminal
 Olomoucine II
CDK1
CDK
12126.147
uM
6.27780
12.38870
 -0.4795 -0.5724 1.1225 0.3405
0.9723
 0.7140
MDA-MB-175-VII
HR+
Luminal
 Olomoucine II
CDK1
CDK
10642.147
uM
5.87280
5.45120
 0.1081 0.1555 5.0000 0.1879
0.9876
 0.6592
MDA-MB-175-VII
HR+
Luminal
 Omipalisib
PI3K
PI3K
10642.087
uM
0.00508
0.01884
 -0.9774 -0.8776 0.7728 1.0945
0.9866
 0.6524
MDA-MB-175-VII
HR+
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7885.011
uM
2.81120
9.54870
 -0.9981 -1.0000 0.8984 0.6797
0.9870
 0.5102
MDA-MB-175-VII
HR+
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7886.011
uM
3.8590
13.20120
 -0.9931 -1.0000 0.8933 0.6301
0.9945
 0.6942
MDA-MB-175-VII
HR+
Luminal
 Oxamflatin
HDAC
HDAC
12126.147
uM
2.58410
7.95250
 -0.9916 -1.0000 0.9773 0.4674
0.9014
 0.7140
MDA-MB-175-VII
HR+
Luminal
 Oxamflatin
HDAC
HDAC
10818.147
uM
1.67690
5.38280
 -0.9992 -1.0000 0.9420 0.5055
0.9397
 0.5138
MDA-MB-175-VII
HR+
Luminal
 Oxamflatin
HDAC
HDAC
10642.147
uM
3.37290
8.7910
 -0.9823 -1.0000 1.1468 0.3430
0.9842
 0.6592
MDA-MB-175-VII
HR+
Luminal
 PD 98059
MEK
MAPK
12126.159
uM
inf
inf
 0.2403 0.2403 0.0000 0.3085
0.5126
 0.7389
MDA-MB-175-VII
HR+
Luminal
 PD 98059
MEK
MAPK
10818.152
uM
29.4730
70.4480
 0.2113 -0.9999 1.2606 0.1222
0.8759
 0.4535
MDA-MB-175-VII
HR+
Luminal
 PD 98059
MEK
MAPK
10642.136
uM
10.99880
71.86580
 -0.0923 -1.0000 0.5853 0.2623
0.9094
 0.5193
MDA-MB-175-VII
HR+
Luminal
 PD184352
MEK
MAPK
12126.155
uM
inf
inf
 0.6531 0.6531 0.0000 0.2138
0.3654
 0.6799
MDA-MB-175-VII
HR+
Luminal
 PD184352
MEK
MAPK
12126.155
uM
inf
inf
 0.6531 0.6531 0.0000 0.2138
0.3654
 0.6799
MDA-MB-175-VII
HR+
Luminal
 PD184352
MEK
MAPK
10818.155
uM
inf
inf
 0.4077 0.4077 0.0000 0.1609
0.5531
 0.6048
MDA-MB-175-VII
HR+
Luminal
 PD184352
MEK
MAPK
10818.155
uM
inf
inf
 0.4077 0.4077 0.0000 0.1609
0.5531
 0.6048
MDA-MB-175-VII
HR+
Luminal
 PD184352
MEK
MAPK
10642.146
uM
35.58260
291.5310
 0.3627 -1.0000 0.5223 0.1405
0.9244
 0.7272
MDA-MB-175-VII
HR+
Luminal
 PD184352
MEK
MAPK
10642.146
uM
35.58260
291.5310
 0.3627 -1.0000 0.5223 0.1405
0.9244
 0.7272