Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 7885.016 | uM | 0.68545 | 0.83069 | -0.0609 | -0.2089 | 1.8163 | 0.5515 | 0.8040 | 0.7137 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 7886.016 | uM | 0.36639 | 0.83092 | -0.7454 | -0.7872 | 1.1548 | 0.7658 | 0.9831 | 0.7194 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1478 | EGFR | ErbB | 7884.016 | uM | 0.94029 | 1.49620 | -0.9477 | -0.9023 | 2.2201 | 0.6875 | 0.9970 | 0.4603 | |
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12126.158 | uM | 34.97860 | 116.4930 | 0.2233 | -1.0000 | 0.9132 | 0.1257 | 0.8248 | 0.5992 | |
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10818.153 | uM | 2.91930 | 51.8650 | 0.0076 | -1.0000 | 0.3818 | 0.2888 | 0.8380 | 0.6469 | |
| MDA-MB-175-VII | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10642.141 | uM | 1.67410 | 6.99740 | -0.8954 | -1.0000 | 0.7681 | 0.3930 | 0.9743 | 0.4059 | |
| MDA-MB-175-VII | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10818.072 | uM | 3.08970 | 143.59610 | -0.2313 | -1.0000 | 0.2862 | 0.4022 | 0.7539 | 0.4268 | |
| MDA-MB-175-VII | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10642.072 | uM | 61.49540 | 54.22780 | 0.2283 | 0.2247 | 4.7456 | 0.0399 | 0.9746 | 0.5405 | |
| MDA-MB-175-VII | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7500.074 | uM | 0.03062 | 0.04882 | -0.9778 | -0.9038 | 2.2134 | 1.2563 | 0.8039 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7500.074 | uM | 0.03062 | 0.04882 | -0.9778 | -0.9038 | 2.2134 | 1.2563 | 0.8039 | 0.5279 | |
| MDA-MB-175-VII | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7499.074 | uM | 0.02955 | 0.04423 | -0.9307 | -0.7788 | 2.3281 | 1.1149 | 0.9804 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7499.074 | uM | 0.02955 | 0.04423 | -0.9307 | -0.7788 | 2.3281 | 1.1149 | 0.9804 | 0.7239 | |
| MDA-MB-175-VII | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14759.203 | uM | 0.01669 | 0.02621 | -0.8345 | -0.8419 | 2.1869 | 1.1312 | 0.9990 | 1.7099 | |
| MDA-MB-175-VII | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14759.203 | uM | 0.01669 | 0.02621 | -0.8345 | -0.8419 | 2.1869 | 1.1312 | 0.9990 | 1.7099 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 12126.145 | uM | 0.87111 | 1.69890 | -0.7430 | -0.7354 | 1.3542 | 0.6168 | 0.9663 | 0.6493 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 10818.145 | uM | 0.78990 | 1.5230 | -0.6746 | -0.6590 | 1.2804 | 0.5957 | 0.9707 | 0.4621 | |
| MDA-MB-175-VII | HR+ | Luminal | Bosutinib | Src | nRTK | 10642.145 | uM | 0.51831 | 1.29010 | -0.7394 | -0.7610 | 1.0143 | 0.5994 | 0.9722 | 0.3537 | |
| MDA-MB-175-VII | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7885.011 | uM | 39.67170 | 72.13610 | -0.9959 | -1.0000 | 1.8374 | 0.4809 | 0.9908 | 0.5102 | |
| MDA-MB-175-VII | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7886.011 | uM | 35.11440 | 64.70520 | -0.9956 | -1.0000 | 1.7974 | 0.4664 | 0.9966 | 0.6942 | |
| MDA-MB-175-VII | HR+ | Luminal | Celecoxib | COX2 | COX | 10642.136 | uM | inf | inf | 0.5259 | 0.5259 | 0.0000 | 0.1780 | 0.0542 | 0.5193 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7885.042 | uM | inf | inf | 1.0037 | 1.0037 | 0.0000 | 0.0264 | 0.1320 | 0.5912 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7886.042 | uM | inf | inf | 0.9528 | 0.9528 | 0.0000 | -0.0085 | 0.3806 | 0.6462 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7884.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6074 | |
| MDA-MB-175-VII | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7884.018 | uM | 81.71750 | 1000.00000 | -0.6812 | -0.9773 | 0.4326 | 0.3773 | 0.7436 | 0.6074 | ||
| MDA-MB-175-VII | HR+ | Luminal | Chk2 inhibitor II | CHK2 | CHK | 10642.14 | uM | inf | inf | -0.0424 | -0.0424 | 0.0000 | 0.3159 | 0.3366 | 0.5473 |