Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 12594.143 | uM | 916.46090 | 1000.00000 | -0.3689 | -0.0768 | 1.6381 | 0.1589 | 0.8818 | 1.2787 | |
| MDA-MB-157 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7879.018 | uM | 0.01095 | 0.01390 | -0.8224 | -0.5276 | 3.0160 | 0.9319 | 0.9746 | 1.7910 | |
| MDA-MB-157 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7496.065 | uM | 41.47270 | 125.65610 | -0.9892 | -1.0000 | 0.9911 | 0.8316 | 0.9879 | 0.9526 | |
| MDA-MB-157 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7498.065 | uM | 97.37520 | 282.68360 | -0.9511 | -0.9987 | 1.0300 | 0.6769 | 0.9904 | 1.1827 | |
| MDA-MB-157 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7495.065 | uM | 104.58780 | 290.32910 | -0.9622 | -0.9937 | 1.0719 | 0.6489 | 0.9959 | 1.2645 | |
| MDA-MB-157 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 12594.171 | uM | 1.15160 | 1.29590 | -0.4131 | -0.4009 | 4.9898 | 0.4881 | 0.9981 | 1.1797 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14931.189 | uM | 0.29551 | 0.47282 | -0.9943 | -1.0000 | 2.3374 | 0.8198 | 0.9893 | 0.6183 | |
| MDA-MB-157 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14218.189 | uM | 0.37189 | 0.69466 | -0.9583 | -0.9523 | 1.7066 | 0.7217 | 0.9959 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12594.169 | uM | inf | 1.39890 | 0.4251 | 0.5148 | 5.0000 | 0.1418 | 0.9474 | 1.4097 | |
| MDA-MB-175-VII | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7884.016 | uM | inf | inf | 1.0238 | 1.0238 | 0.0000 | -0.0464 | -32.8843 | 0.4603 | ||
| MDA-MB-175-VII | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7885.016 | uM | inf | inf | 0.7529 | 0.7529 | 0.0000 | 0.1378 | 0.2398 | 0.7137 | ||
| MDA-MB-175-VII | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7886.016 | uM | 10.34850 | 9.38870 | -0.1312 | 0.1927 | 5.0000 | 0.2243 | 0.7564 | 0.7194 | ||
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7886.05 | uM | 0.03098 | 0.04960 | -0.9986 | -0.7268 | 1.9069 | 0.9833 | 0.9782 | 0.6254 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7885.05 | uM | 0.01442 | 0.02938 | -0.8685 | -0.6928 | 1.2214 | 1.0607 | 0.9817 | 0.6518 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7886.04 | uM | 0.05273 | 0.06706 | -0.7856 | -0.6085 | 3.3117 | 0.9362 | 0.9853 | 0.7771 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7885.037 | uM | 0.03688 | 0.05497 | -0.8073 | -0.6731 | 2.1373 | 0.9690 | 0.9919 | 0.6907 | |
| MDA-MB-175-VII | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7884.05 | uM | 0.02659 | 0.03251 | -0.9340 | -0.8649 | 5.0000 | 1.1490 | 0.9980 | 0.3869 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10818.143 | uM | 6.06410 | 1000.00000 | -0.4041 | -0.9489 | 0.2084 | 0.5572 | 0.8336 | 0.6263 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12126.143 | uM | 0.47434 | 0.49747 | -0.4005 | -0.0875 | 3.3888 | 0.7850 | 0.8672 | 0.6729 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10642.143 | uM | 7.22710 | 325.88040 | -0.5472 | -1.0000 | 0.2885 | 0.6114 | 0.8883 | 0.5076 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7885.017 | uM | 68.30750 | 288.83820 | -0.9570 | -1.0000 | 0.7620 | 0.6648 | 0.9889 | 0.5647 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7886.017 | uM | 133.62210 | 479.01180 | -0.8971 | -1.0000 | 0.8605 | 0.5873 | 0.9930 | 0.7230 | |
| MDA-MB-175-VII | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12126.158 | uM | 0.00446 | 0.01986 | -0.9994 | -1.0000 | 0.7352 | 1.3131 | 0.8929 | 0.5992 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1024 | IGF1R | RTK | 7500.066 | uM | inf | inf | 0.4961 | 0.4961 | 0.0000 | 0.1427 | 0.3937 | 0.7802 | |
| MDA-MB-175-VII | HR+ | Luminal | AG1024 | IGF1R | RTK | 7499.066 | uM | 13.30920 | 34.13550 | 0.0061 | -1.0000 | 1.1664 | 0.1173 | 0.9495 | 0.7917 |