Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7893.001 | uM | 0.03312 | 0.01644 | 0.2564 | 0.4849 | 4.9996 | 0.2921 | 0.8605 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7892.001 | uM | 0.07006 | 0.05153 | -0.0952 | 0.1660 | 1.3130 | 0.3922 | 0.9207 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7893.001 | uM | 0.09236 | 0.05367 | 0.0130 | 0.2306 | 1.1393 | 0.3696 | 0.9207 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7504.091 | uM | 20.47270 | 36.0860 | -0.9636 | -0.9970 | 1.9346 | 0.4817 | 0.9898 | 1.9941 | |
| MDA-MB-231 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7504.067 | uM | 0.09221 | 1.02460 | -0.9685 | -1.0000 | 0.4562 | 0.5660 | 0.8950 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7504.095 | uM | 0.00069 | 0.11642 | -0.9613 | -1.0000 | 0.2143 | 0.9276 | 0.7141 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7504.098 | uM | inf | inf | 1.0397 | 1.0397 | 0.0000 | -0.0333 | -0.9550 | 1.8959 | |
| MDA-MB-231 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7504.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0371 | -3.9735 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Nutlin 3a | MDM2 | MDM2 | 7504.066 | uM | 81.25090 | 65.26570 | 0.6427 | 0.3200 | 4.6641 | -0.0184 | 0.8832 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7892.011 | uM | 59.00920 | 382.57620 | -0.1767 | -1.0000 | 0.5877 | 0.2215 | 0.9889 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7504.095 | uM | inf | inf | 0.9438 | 0.9438 | 0.0000 | -0.0266 | -0.1642 | 2.0796 | |
| MDA-MB-231 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7504.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0441 | -20.3886 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7504.067 | uM | inf | 32.55750 | 0.5998 | 0.5789 | 1.7976 | 0.0345 | 0.9580 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7504.069 | uM | inf | inf | 1.0328 | 1.0328 | 0.0000 | -0.0478 | -66.7663 | 1.8361 | |
| MDA-MB-231 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7504.084 | uM | inf | 7.15930 | 0.7354 | 0.8400 | 4.8199 | 0.0437 | 0.7230 | 1.8866 | |
| MDA-MB-231 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7504.067 | uM | 8.21570 | 12.30310 | -0.9685 | -0.9683 | 2.6677 | 0.3604 | 0.9976 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Taxol | TUBB | TUBB | 7893.002 | uM | 0.0130 | 0.01253 | -0.1441 | 0.0160 | 0.8926 | 0.5858 | 0.9687 | 2.3454 | |
| MDA-MB-231 | TNBC | Basal B | Taxol | TUBB | TUBB | 7892.002 | uM | 0.01991 | 0.01879 | -0.0409 | 0.0326 | 1.1648 | 0.5459 | 0.9917 | 2.4193 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7892.043 | uM | inf | 0.53315 | 0.7945 | 0.7749 | 0.5934 | 0.0977 | 0.7193 | 2.5944 | |
| MDA-MB-231 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7893.007 | uM | 1.16470 | 1.95450 | -0.1181 | -0.1989 | 0.6470 | 0.3749 | 0.9961 | 2.2909 | |
| MDA-MB-231 | TNBC | Basal B | Trametinib | MEK | MAPK | 7892.012 | uM | inf | 0.05174 | 0.5884 | 0.6799 | 2.1441 | 0.1234 | 0.9280 | 2.3881 | |
| MDA-MB-231 | TNBC | Basal B | Trametinib | MEK | MAPK | 7893.05 | uM | inf | 0.04861 | 0.5318 | 0.5810 | 1.7706 | 0.1712 | 0.9746 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7504.065 | uM | 24.38210 | 29.18280 | -0.9183 | -0.7281 | 5.0000 | 0.6791 | 0.9880 | 1.6220 | |
| MDA-MB-231 | TNBC | Basal B | Triciribine | AKT | AKT | 7504.074 | uM | inf | 6.09780 | 0.5573 | 0.5504 | 2.4534 | 0.0410 | 0.9267 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7893.042 | uM | 0.02305 | 3.08920 | -0.7080 | -1.0000 | 0.2243 | 0.6339 | 0.7254 | 2.2789 |