Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10472.087 | uM | 0.00138 | 0.00445 | -0.9999 | -1.0000 | 0.9369 | 1.3934 | 0.9945 | 0.5566 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 7506.086 | uM | 0.06872 | 0.15653 | -0.9119 | -0.9364 | 1.2820 | 0.8101 | 0.9966 | 1.0496 | |
| MDA-MB-361 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10643.087 | uM | 0.00172 | 0.00488 | -1.0000 | -0.9991 | 1.0559 | 1.3640 | 0.9987 | 0.6516 | |
| MDA-MB-361 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10095.021 | uM | 6.92450 | 24.19920 | -0.9770 | -1.0000 | 0.8780 | 0.5196 | 0.9683 | 0.9164 | |
| MDA-MB-361 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7896.011 | uM | 3.33450 | 20.37360 | -0.8165 | -1.0000 | 0.6070 | 0.5952 | 0.9752 | 1.0906 | |
| MDA-MB-361 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9648.011 | uM | 2.70140 | 12.81970 | -0.9671 | -1.0000 | 0.7055 | 0.6578 | 0.9823 | 0.6920 | |
| MDA-MB-361 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 12379.147 | uM | 1.70740 | 2.12590 | -1.0000 | -0.9966 | 5.0000 | 0.6457 | 0.9056 | 0.3192 | |
| MDA-MB-361 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 10999.147 | uM | 0.66394 | 1.38840 | -0.9819 | -1.0000 | 1.4893 | 0.6270 | 0.9960 | 0.9239 | |
| MDA-MB-361 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 10643.147 | uM | 0.76279 | 1.21570 | -0.9997 | -1.0000 | 2.3572 | 0.6131 | 0.9972 | 0.6347 | |
| MDA-MB-361 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 10999.152 | uM | inf | inf | 0.7974 | 0.7974 | 0.0000 | 0.0618 | 0.2809 | 0.8426 | |
| MDA-MB-361 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 12379.152 | uM | inf | inf | 0.6460 | 0.6460 | 0.0000 | 0.0583 | 0.5083 | 0.5297 | |
| MDA-MB-361 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 10643.136 | uM | 44.73990 | 167.11890 | 0.2680 | -0.7931 | 0.7210 | 0.0905 | 0.9753 | 0.5141 | |
| MDA-MB-361 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 10472.1 | uM | 0.61567 | 3.65480 | -0.9996 | -1.0000 | 0.6168 | 0.5186 | 0.9414 | 0.6324 | |
| MDA-MB-361 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 7506.093 | uM | 14.08040 | 17.54040 | -0.9283 | -1.0000 | 5.0000 | 0.0984 | 0.9958 | 0.9162 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9030 | 0.9030 | 0.0000 | -0.0123 | -0.1189 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9030 | 0.9030 | 0.0000 | -0.0123 | -0.1189 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10643.146 | uM | inf | inf | 0.7735 | 0.7735 | 0.0000 | 0.0162 | 0.1132 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10643.146 | uM | inf | inf | 0.7735 | 0.7735 | 0.0000 | 0.0162 | 0.1132 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12379.155 | uM | inf | 6.66430 | 0.6251 | 0.6250 | 5.0000 | 0.0334 | 0.8721 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | PD184352 | MEK | MAPK | 12379.155 | uM | inf | 6.66430 | 0.6251 | 0.6250 | 5.0000 | 0.0334 | 0.8721 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7507.094 | uM | inf | inf | 0.0352 | 0.0352 | 0.0000 | 0.6740 | 0.2984 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7506.095 | uM | 0.56960 | 0.31142 | 0.3131 | 0.3084 | 1.5885 | 0.5252 | 0.7455 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7508.095 | uM | 0.27437 | 0.38754 | -0.5045 | -0.4429 | 1.8368 | 1.0164 | 0.9902 | 0.7473 | |
| MDA-MB-361 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7507.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0025 | -0.0079 | 1.0148 | |
| MDA-MB-361 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7508.065 | uM | inf | inf | 1.0103 | 1.0103 | 0.0000 | 0.0104 | 0.0000 | 0.7854 |