Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MX1
Unknown
Unknown
 ICRF-193
TOP2
TOP
12220.157
uM
1.33310
1.51960
 -0.2718 -0.1920 2.4825 0.3361
0.9793
 0.3325
MX1
Unknown
Unknown
 Imatinib
ABL/KIT/PDGFR
nRTK
7523.091
uM
22.57330
32.56670
 -0.9939 -1.0000 2.9974 0.5055
0.9856
 0.9283
MX1
Unknown
Unknown
 Ispinesib
KSP
Kinesin
7523.067
uM
0.02589
0.03350
 -0.9940 -0.5387 2.8366 0.8345
0.9281
 0.8380
MX1
Unknown
Unknown
 Ixabepilone
TUBB
TUBB
7523.095
uM
0.00352
0.00868
 -0.9962 -0.5118 0.7800 0.9478
0.8877
 0.8203
MX1
Unknown
Unknown
 JNK-IN-5A
JNK
JNK
12220.144
uM
0.34907
15.26840
 -0.6997 -1.0000 0.2908 0.5440
0.6171
 0.5126
MX1
Unknown
Unknown
 JNK-IN-5A
JNK
JNK
10874.144
uM
1.29420
1.47110
 -0.3945 -0.4490 5.0000 0.4626
0.9512
 0.7282
MX1
Unknown
Unknown
 JNK-IN-5A
JNK
JNK
10644.144
uM
0.67463
0.82228
 -0.8841 -0.8450 5.0000 0.8246
0.9625
 0.5357
MX1
Unknown
Unknown
 L-779450
BRAF
MAPK
12220.161
uM
10.59690
13.19760
 -0.9933 -0.9959 4.9931 0.1804
0.9423
 0.4684
MX1
Unknown
Unknown
 L-779450
BRAF
MAPK
10644.137
uM
6.30710
8.48390
 -0.9907 -1.0000 3.7054 0.2296
0.9774
 0.5827
MX1
Unknown
Unknown
 L-779450
BRAF
MAPK
10874.149
uM
19.42320
24.16740
 -0.6573 -0.9909 4.9993 0.1170
0.9794
 0.8239
MX1
Unknown
Unknown
 Lapatinib
EGFR/HER2
ErbB
7523.098
uM
6.63380
2.54580
 0.4285 0.4077 1.7638 0.0965
0.9732
 0.8897
MX1
Unknown
Unknown
 LBH589
HDAC
HDAC
10874.154
uM
0.06423
0.11763
 -0.9921 -0.9928 1.8075 0.8595
0.9989
 0.7639
MX1
Unknown
Unknown
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10644.142
uM
0.05884
0.18232
 -0.9999 -1.0000 0.9714 1.0132
0.9422
 0.5163
MX1
Unknown
Unknown
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10874.154
uM
0.06032
0.34228
 -0.9969 -1.0000 0.6329 0.7495
0.9768
 0.7639
MX1
Unknown
Unknown
 Mebendazole
12667.174
uM
0.32772
0.39909
 -0.3630 -0.2626 2.1427 0.4878
0.9911
 0.8129
MX1
Unknown
Unknown
 Methotrexate
DHFR
Metabolism
7523.084
uM
0.01347
0.01123
 0.0951 0.1144 1.4276 0.7084
0.9608
 0.9069
MX1
Unknown
Unknown
 Methylglyoxal
13567.184
uM
468.21670
705.16970
 -0.9987 -1.0000 2.6828 0.7669
0.9728
 0.6921
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14278.189
uM
inf
inf
 -0.9921 -0.9921 0.0000 0.7370
0.5547
 0.7296
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14278.189
uM
inf
inf
 -0.9921 -0.9921 0.0000 0.7370
0.5547
 0.7296
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14649.189
uM
0.36725
0.45735
 -0.9992 -0.9978 5.0000 0.7780
0.9985
 0.5692
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
14649.189
uM
0.36725
0.45735
 -0.9992 -0.9978 5.0000 0.7780
0.9985
 0.5692
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10644.145
uM
0.04734
0.07256
 -1.0000 -1.0000 2.5730 1.0527
0.9991
 0.4300
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10644.145
uM
0.04734
0.07256
 -1.0000 -1.0000 2.5730 1.0527
0.9991
 0.4300
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10874.145
uM
0.12033
0.15614
 -0.9820 -0.9785 4.1620 0.8984
0.9993
 0.8505
MX1
Unknown
Unknown
 MG-132
Proteasome
Proteasome
10874.145
uM
0.12033
0.15614
 -0.9820 -0.9785 4.1620 0.8984
0.9993
 0.8505