Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 12220.155 | uM | 0.05270 | 0.04425 | 0.3317 | 0.1050 | 1.3492 | 0.5392 | 0.5953 | 0.4858 | |
| MX1 | Unknown | Unknown | Dactolisib | PI3K | PI3K | 10874.155 | uM | 0.32798 | 0.32914 | -0.0994 | -0.0089 | 5.0000 | 0.4070 | 0.7599 | 0.8099 | |
| MX1 | Unknown | Unknown | Dichloroacetate | PDK | PDK | 12667.176 | uM | inf | 4.29670 | 0.8312 | 0.5377 | 2.1949 | -0.0009 | 0.7580 | 0.7898 | |
| MX1 | Unknown | Unknown | Disulfiram | Proteasome | Proteasome | 12667.174 | uM | 23.75230 | 41.06080 | -0.4553 | -1.0000 | 2.0071 | 0.1982 | 0.8248 | 0.8129 | |
| MX1 | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7523.091 | uM | 5.14080 | 33.22490 | -0.2637 | -1.0000 | 0.5887 | 0.3002 | 0.9420 | 0.9283 | |
| MX1 | Unknown | Unknown | Etoposide | TOP2 | TOP | 7523.074 | uM | 0.42937 | 3.08010 | -0.9272 | -1.0000 | 0.5576 | 0.7614 | 0.9701 | 0.8505 | |
| MX1 | Unknown | Unknown | Everolimus | MTOR | MTOR | 10874.156 | uM | 0.71673 | 6.36150 | -0.9965 | -1.0000 | 0.5032 | 0.4598 | 0.8230 | 0.6949 | |
| MX1 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 7523.084 | uM | 0.2830 | 0.38925 | -0.9917 | -1.0000 | 3.4462 | 0.7612 | 0.9801 | 0.9069 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 10644.137 | uM | inf | inf | 0.7785 | 0.7785 | 0.0000 | 0.0679 | -0.0208 | 0.5827 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 10874.149 | uM | inf | inf | 0.9293 | 0.9293 | 0.0000 | 0.0534 | 0.0000 | 0.8239 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 12220.161 | uM | 75.19810 | 93.67660 | -0.1619 | -1.0000 | 5.0000 | 0.2264 | 0.6037 | 0.4684 | |
| MX1 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 10874.154 | uM | inf | inf | 0.9041 | 0.9041 | 0.0000 | 0.0469 | 0.0000 | 0.7639 | |
| MX1 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 10644.142 | uM | inf | inf | 0.7386 | 0.7386 | 0.0000 | 0.0345 | 0.4867 | 0.5163 | |
| MX1 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 10874.15 | uM | 0.88473 | 3.17410 | -0.7532 | -1.0000 | 0.8600 | 0.4557 | 0.9604 | 0.9133 | ||
| MX1 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 10644.138 | uM | 0.78829 | 1.08180 | -0.9417 | -0.8723 | 3.1901 | 0.5509 | 0.9775 | 0.5624 | ||
| MX1 | Unknown | Unknown | Glycyl-H-1152 | ROCK2 | 12220.16 | uM | 1.76170 | 2.80350 | -0.8731 | -0.8256 | 2.0988 | 0.4561 | 0.9805 | 0.4410 | ||
| MX1 | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7523.098 | uM | inf | inf | -0.9338 | -0.9338 | 0.0000 | 0.2892 | 0.5703 | 0.8897 | |
| MX1 | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7523.071 | uM | 4.94450 | 7.19880 | -0.9822 | -0.9910 | 2.9086 | 0.5067 | 0.9690 | 0.9945 | |
| MX1 | Unknown | Unknown | GSK1838705A | IGF1R | RTK | 7523.091 | uM | 6.34750 | 8.17840 | -0.9805 | -0.9864 | 4.2990 | 0.5096 | 0.9698 | 0.9283 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 10644.139 | uM | inf | inf | 0.8049 | 0.8049 | 0.0000 | 0.0886 | 0.2257 | 0.6077 | |
| MX1 | Unknown | Unknown | Ibandronate | FDPS | 12220.143 | uM | 51.18350 | 329.6960 | -0.5371 | -1.0000 | 0.5898 | 0.4324 | 0.6251 | 0.4532 | ||
| MX1 | Unknown | Unknown | Ibandronate | FDPS | 10644.143 | uM | 70.98440 | 315.23990 | -0.4930 | -1.0000 | 0.7369 | 0.4141 | 0.8107 | 0.6221 | ||
| MX1 | Unknown | Unknown | Ibandronate | FDPS | 10874.143 | uM | 96.97760 | 104.02310 | -0.0944 | -0.0921 | 2.4107 | 0.2018 | 0.9910 | 0.7639 | ||
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 10644.139 | uM | 0.69228 | 0.47362 | 0.1524 | 0.1921 | 1.2770 | 0.3322 | 0.8021 | 0.6077 | |
| MX1 | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 10874.151 | uM | 2.00250 | 1.04220 | 0.3000 | 0.2947 | 1.3628 | 0.2036 | 0.9402 | 0.7476 |