Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7512.095 | uM | 0.00042 | 0.10389 | -0.9926 | -1.0000 | 0.1993 | 0.9414 | 0.6868 | 0.8452 | |
| MDA-MB-415 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7511.095 | uM | 1.3150 | 0.69985 | 0.3287 | 0.4157 | 2.8230 | 0.2318 | 0.8449 | 1.1565 | |
| MDA-MB-415 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10938.144 | uM | inf | inf | 0.4357 | 0.4357 | 0.0000 | 0.4162 | 0.0687 | 1.1369 | |
| MDA-MB-415 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12333.168 | uM | 0.38751 | 0.40503 | -0.0482 | -0.1237 | 4.9998 | 0.5489 | 0.9553 | 0.5815 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10938.149 | uM | inf | inf | 0.7318 | 0.7318 | 0.0000 | 0.2167 | 0.1498 | 1.0006 | |
| MDA-MB-415 | HR+ | Luminal | L-779450 | BRAF | MAPK | 12333.166 | uM | 12.91650 | 37.99290 | 0.0293 | -1.0000 | 1.0183 | 0.1891 | 0.7508 | 0.6353 | |
| MDA-MB-415 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7510.098 | uM | inf | inf | 0.9619 | 0.9619 | 0.0000 | 0.0329 | -0.0298 | 0.9528 | |
| MDA-MB-415 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7512.098 | uM | inf | inf | 0.9367 | 0.9367 | 0.0000 | 0.0880 | 0.1521 | 0.9499 | |
| MDA-MB-415 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7511.098 | uM | inf | inf | 0.9618 | 0.9618 | 0.0000 | 0.0309 | 0.2078 | 1.2032 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 10938.154 | uM | 0.05087 | 0.07103 | -0.9778 | -0.9703 | 3.2310 | 1.0859 | 0.8640 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | LBH589 | HDAC | HDAC | 12333.167 | uM | 0.01363 | 0.03470 | -0.9941 | -0.9889 | 1.1673 | 1.0780 | 0.9927 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10938.154 | uM | 0.33007 | 2.30970 | -0.9714 | -1.0000 | 0.5647 | 0.5834 | 0.7181 | 1.0425 | |
| MDA-MB-415 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12333.167 | uM | 0.28479 | 0.83232 | -0.9958 | -1.0000 | 1.0244 | 0.7097 | 0.9104 | 0.6809 | |
| MDA-MB-415 | HR+ | Luminal | Mebendazole | 12959.174 | uM | 0.37016 | 5.03160 | -0.2608 | -0.8222 | 0.3727 | 0.5042 | 0.9457 | 0.5020 | |||
| MDA-MB-415 | HR+ | Luminal | Mebendazole | 13587.174 | uM | 0.32163 | 0.37879 | -0.2050 | -0.1694 | 1.7834 | 0.5079 | 0.9728 | 0.6955 | |||
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7512.084 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0491 | -524.0720 | 0.7511 | |
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7510.084 | uM | inf | inf | 0.8517 | 0.8517 | 0.0000 | 0.0588 | 0.1386 | 0.8702 | |
| MDA-MB-415 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7511.084 | uM | inf | 0.03357 | 0.4726 | 0.5052 | 5.0000 | 0.3425 | 0.9922 | 1.1467 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10938.145 | uM | 0.02276 | 0.20522 | -0.7075 | -0.8569 | 0.4540 | 0.8670 | 0.9728 | 1.1073 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10938.145 | uM | 0.02276 | 0.20522 | -0.7075 | -0.8569 | 0.4540 | 0.8670 | 0.9728 | 1.1073 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12333.17 | uM | 0.18041 | 0.35077 | -0.9948 | -1.0000 | 1.6523 | 0.8729 | 0.9841 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12333.17 | uM | 0.18041 | 0.35077 | -0.9948 | -1.0000 | 1.6523 | 0.8729 | 0.9841 | 0.6683 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14272.189 | uM | 1.04350 | 1.35260 | -0.9797 | -0.8110 | 3.7152 | 0.5702 | 0.9908 | 0.5095 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14272.189 | uM | 1.04350 | 1.35260 | -0.9797 | -0.8110 | 3.7152 | 0.5702 | 0.9908 | 0.5095 | |
| MDA-MB-415 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14643.189 | uM | 1.46630 | 2.07980 | -0.9457 | -0.9390 | 3.0242 | 0.5668 | 0.9947 | 0.8604 |