Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7506.067 | uM | 0.03511 | 0.03878 | -0.9746 | -0.3216 | 4.9997 | 0.6543 | 0.8706 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7507.067 | uM | 0.03738 | 0.06798 | -0.9869 | -0.5240 | 1.1986 | 0.6951 | 0.9190 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7508.067 | uM | 0.02564 | 0.03092 | -0.9972 | -0.7743 | 5.0000 | 0.9845 | 0.9860 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7507.094 | uM | 0.00188 | 0.00206 | -0.9825 | -0.1760 | 3.3449 | 1.0669 | 0.5812 | 1.0418 | |
| MDA-MB-361 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7506.095 | uM | 0.03380 | 1.09640 | -0.9094 | -1.0000 | 0.3158 | 0.6282 | 0.7565 | 1.2246 | |
| MDA-MB-361 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7508.095 | uM | 0.00087 | 0.00130 | -0.9942 | -0.6037 | 1.9635 | 1.2595 | 0.9267 | 0.7473 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10999.144 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.1189 | 0.2272 | 0.6880 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 10643.144 | uM | 1.22940 | 1.27550 | -0.1900 | -0.1011 | 5.0000 | 0.4149 | 0.9666 | 0.7178 | |
| MDA-MB-361 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12379.168 | uM | 128.15820 | 159.58180 | -0.5091 | -0.9968 | 5.0000 | 0.0519 | 0.9920 | 0.4672 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10999.149 | uM | 35.93160 | 33.8310 | 0.5820 | 0.1300 | 4.9999 | 0.0319 | 0.7804 | 0.7265 | |
| MDA-MB-361 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10643.137 | uM | 21.68760 | 25.86030 | -0.0358 | -0.4483 | 3.6377 | 0.0273 | 0.9843 | 0.6468 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7507.098 | uM | inf | 0.63101 | 0.4884 | 0.5122 | 1.1776 | 0.1554 | 0.8619 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7508.098 | uM | 1.07120 | 0.92891 | 0.1071 | 0.1218 | 1.9594 | 0.1820 | 0.9849 | 0.7973 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 12379.167 | uM | 0.02259 | 0.04640 | -0.9993 | -1.0000 | 1.5262 | 1.0200 | 0.9966 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 10999.154 | uM | 0.04815 | 0.05993 | -0.9942 | -0.9925 | 5.0000 | 0.9430 | 0.9993 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10643.142 | uM | 0.20699 | 0.79038 | -1.0000 | -1.0000 | 0.8199 | 0.7668 | 0.9906 | 0.5166 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10999.154 | uM | 0.47621 | 1.62420 | -0.9885 | -1.0000 | 0.8954 | 0.4670 | 0.9931 | 0.7027 | |
| MDA-MB-361 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12379.167 | uM | 0.36226 | 0.72106 | -0.9998 | -1.0000 | 1.5960 | 0.5879 | 0.9969 | 0.5212 | |
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 12989.174 | uM | 0.28312 | 0.41260 | -0.2138 | -0.2632 | 1.1230 | 0.5669 | 0.9341 | 0.7084 | |||
| MDA-MB-361 | HER2amp | Luminal | Mebendazole | 13558.174 | uM | 0.13235 | 0.17640 | -0.5250 | -0.3853 | 1.9883 | 0.6890 | 0.9531 | 0.5699 | |||
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7507.084 | uM | 0.12833 | 0.12072 | 0.1154 | 0.1317 | 5.0000 | 0.5359 | 0.9870 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7506.085 | uM | 0.15033 | 0.11298 | 0.3497 | 0.3730 | 4.7973 | 0.3880 | 0.9923 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7508.084 | uM | 0.13858 | 0.16471 | -0.3345 | -0.3322 | 2.9496 | 0.7967 | 0.9953 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Methylglyoxal | 13516.184 | uM | 483.18040 | 1000.00000 | -0.9997 | -0.7768 | 1.2889 | 0.4930 | 0.9292 | 0.5643 | |||
| MDA-MB-361 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10999.145 | uM | 0.24275 | 0.36523 | -0.9665 | -0.8735 | 2.4738 | 0.7991 | 0.9823 | 0.7621 |