Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7886.042 | uM | 0.00036 | 0.14006 | -0.9919 | -1.0000 | 0.1845 | 0.9309 | 0.7305 | 0.6462 | |
| MDA-MB-175-VII | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7884.018 | uM | 0.01806 | 0.44303 | -0.9591 | -1.0000 | 0.3433 | 0.7491 | 0.8263 | 0.6074 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7500.065 | uM | 70.24580 | 270.90780 | -0.9605 | -1.0000 | 0.8139 | 0.7096 | 0.9837 | 0.8201 | |
| MDA-MB-175-VII | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7499.065 | uM | 33.55520 | 112.63410 | -0.9811 | -1.0000 | 0.9072 | 0.8235 | 0.9891 | 0.5419 | |
| MDA-MB-175-VII | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12126.157 | uM | 1.53120 | 1.28120 | 0.2472 | 0.2949 | 5.0000 | 0.3479 | 0.6402 | 0.7555 | |
| MDA-MB-175-VII | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10818.151 | uM | 1.0610 | 0.97420 | 0.1296 | 0.1738 | 5.0000 | 0.3564 | 0.9578 | 0.4459 | |
| MDA-MB-175-VII | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10642.139 | uM | 2.93070 | 2.40660 | 0.1064 | 0.1559 | 1.8966 | 0.2717 | 0.9629 | 0.7017 | |
| MDA-MB-175-VII | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14619.189 | uM | 0.91694 | 1.2040 | -0.8637 | -0.8602 | 3.6740 | 0.6116 | 0.9970 | 1.2787 | |
| MDA-MB-175-VII | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14269.189 | uM | 0.38947 | 0.64726 | -0.9855 | -0.9971 | 2.1589 | 0.7210 | 0.9979 | 0.5173 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 10818.15 | uM | 2.14740 | 999.68010 | 0.2751 | -0.7643 | 0.1510 | 0.3469 | 0.6844 | 0.4390 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 10642.138 | uM | 19.16960 | 29.1850 | -0.9994 | -1.0000 | 2.6137 | 0.4105 | 0.7449 | 0.5620 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 12126.16 | uM | 55.9990 | 219.56940 | 0.4954 | -0.0915 | 0.1230 | 0.3282 | 0.7819 | 0.6930 | |
| MDA-MB-231 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7892.016 | uM | inf | inf | 0.9547 | 0.9547 | 0.0000 | 0.0102 | 0.5298 | 2.3475 | ||
| MDA-MB-231 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7893.016 | uM | inf | 19.83710 | 0.9104 | 0.9100 | 4.9988 | -0.0081 | 0.6344 | 2.2064 | ||
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7893.05 | uM | 1.95060 | 1.91370 | -0.0860 | 0.0152 | 1.6165 | 0.2775 | 0.9811 | 2.2255 | |
| MDA-MB-231 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7892.037 | uM | 2.09540 | 2.01480 | -0.0092 | 0.0346 | 1.8304 | 0.2984 | 0.9940 | 2.5183 | |
| MDA-MB-231 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7892.017 | uM | 389.45810 | 1000.00000 | -0.0878 | -0.3037 | 0.5033 | 0.3259 | 0.9883 | 2.4495 | |
| MDA-MB-231 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7893.017 | uM | 436.47320 | 1000.00000 | -0.1099 | -0.2918 | 0.5545 | 0.3222 | 0.9928 | 2.2898 | |
| MDA-MB-231 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7504.066 | uM | 38.27430 | 34.52950 | 0.6357 | 0.2000 | 4.9601 | -0.0189 | 0.8930 | 1.8487 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7893.016 | uM | inf | inf | 1.0032 | 1.0032 | 0.0000 | -0.0097 | -0.1970 | 2.2064 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7892.016 | uM | inf | inf | 0.9839 | 0.9839 | 0.0000 | -0.0090 | -0.1042 | 2.3475 | |
| MDA-MB-231 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7504.074 | uM | 0.09433 | 0.12339 | -0.8488 | -0.8128 | 3.5944 | 0.9992 | 0.9985 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7504.074 | uM | 0.09433 | 0.12339 | -0.8488 | -0.8128 | 3.5944 | 0.9992 | 0.9985 | 1.8962 | |
| MDA-MB-231 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7892.011 | uM | 351.20130 | 453.11770 | -0.2505 | -0.3681 | 2.1653 | 0.1254 | 0.9974 | 2.6182 | |
| MDA-MB-231 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7893.042 | uM | inf | inf | 0.7448 | 0.7448 | 0.0000 | 0.0660 | 0.1733 | 2.2789 |