Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
MCF 10A	NM	Basal B	(Z)-4-Hydroxytamoxifen	ESR1		7868.016	uM	36.34950	52.46920	-0.9236	-0.9855	2.9666	0.1680	0.9976	2.0998
MCF 10A	NM	Basal B	17-AAG	HSP90	HSP90	7868.05	uM	0.04076	0.06077	-0.7725	-0.4884	1.7067	0.8310	0.9661	2.0672
MCF 10A	NM	Basal B	17-AAG	HSP90	HSP90	7867.04	uM	0.04721	0.06362	-0.7283	-0.4910	2.2943	0.8338	0.9815	2.4460
MCF 10A	NM	Basal B	17-AAG	HSP90	HSP90	7870.037	uM	0.04563	0.06075	-0.5691	-0.4296	2.1655	0.8195	0.9896	2.2561
MCF 10A	NM	Basal B	17-AAG	HSP90	HSP90	9551.037	uM	0.04202	0.05568	-0.6021	-0.4517	2.2857	0.8285	0.9921	2.6200
MCF 10A	NM	Basal B	2-deoxyglucose			12944.177	uM	930.49390	1000.00000	0.0911	-0.0492	1.3017	0.1223	0.9135	2.0477
MCF 10A	NM	Basal B	5-DFUR	TYMS	TYMS	11056.143	uM	29.22540	158.47350	-0.6519	-0.8293	0.5784	0.4979	0.9796	2.8628
MCF 10A	NM	Basal B	5-FU	TYMS	TYMS	9551.017	uM	0.66260	59.67710	-0.7313	-1.0000	0.2441	0.9335	0.8669	2.5886
MCF 10A	NM	Basal B	5-FU	TYMS	TYMS	7867.017	uM	23.57640	103.81940	-0.7470	-0.8718	0.6808	0.7845	0.9842	2.5255
MCF 10A	NM	Basal B	5-FU	TYMS	TYMS	7870.017	uM	30.5580	107.74890	-0.8406	-0.9221	0.8295	0.7835	0.9913	2.0447
MCF 10A	NM	Basal B	Afatinib	EGFR/HER2	ErbB	11056.158	uM	0.07434	0.79930	-0.7360	-0.9684	0.4536	0.6921	0.9465	2.7355
MCF 10A	NM	Basal B	AG1024	IGF1R	RTK	7483.066	uM	inf	999.20810	0.8293	-0.0956	0.5301	0.0302	0.7291	3.2636
MCF 10A	NM	Basal B	AG1024	IGF1R	RTK	7485.066	uM	inf	6.59210	0.5073	0.5072	5.0000	0.0494	0.9857	3.6205
MCF 10A	NM	Basal B	AG1024	IGF1R	RTK	7484.066	uM	7.06120	26.260	-0.0201	-0.8737	0.7695	0.1638	0.9932	2.8312
MCF 10A	NM	Basal B	AG1478	EGFR	ErbB	7868.016	uM	0.23165	0.70481	-0.8186	-0.6695	0.7637	0.6859	0.9588	2.0998
MCF 10A	NM	Basal B	AG1478	EGFR	ErbB	7867.016	uM	0.28079	0.31279	-0.1368	-0.1317	2.1666	0.5483	0.9937	2.2657
MCF 10A	NM	Basal B	AG1478	EGFR	ErbB	7870.016	uM	0.26376	0.28837	-0.1465	-0.1417	2.7964	0.5610	0.9984	2.1045
MCF 10A	NM	Basal B	AS-252424	PI3K	PI3K	11056.158	uM	inf	inf	0.3950	0.3950	0.0000	0.0612	0.4274	2.7355
MCF 10A	NM	Basal B	Baicalein	Lipoxygenase	Metabolism	7485.072	uM	37.17210	29.41280	0.2192	0.2028	2.2221	0.0920	0.9881	3.4800
MCF 10A	NM	Basal B	Baicalein	Lipoxygenase	Metabolism	11056.072	uM	21.73840	12.81670	0.3169	0.3156	1.8883	0.1244	0.9927	2.8988
MCF 10A	NM	Basal B	Bortezomib	Proteasome	Proteasome	7484.074	uM	5.65780	26.0580	-0.7316	-1.0000	0.7193	0.3449	0.9770	2.6137
MCF 10A	NM	Basal B	Bortezomib	Proteasome	Proteasome	7484.074	uM	5.65780	26.0580	-0.7316	-1.0000	0.7193	0.3449	0.9770	2.6137
MCF 10A	NM	Basal B	Bortezomib	Proteasome	Proteasome	7483.074	uM	2.44520	8.40290	-0.5185	-0.7164	0.7202	0.4103	0.9848	3.2613
MCF 10A	NM	Basal B	Bortezomib	Proteasome	Proteasome	7483.074	uM	2.44520	8.40290	-0.5185	-0.7164	0.7202	0.4103	0.9848	3.2613
MCF 10A	NM	Basal B	Bortezomib	Proteasome	Proteasome	7485.074	uM	1.85990	5.45550	-0.5031	-0.6624	0.7840	0.4506	0.9854	3.5413

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)