Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAL-51 | Cediranib | VEGFR/cKIT | RTK | 3.0488 | -0.1033 | 0.1710 | 0.0517 | 1.0331 | 8.8303 | 0.9776 |
| HCC1937 | Cediranib | VEGFR/cKIT | RTK | 7.9267 | 0.2784 | 0.0440 | 0.0316 | 3.5480 | 8.352 | 0.99376 |
| MDA-MB-361 | Cediranib | VEGFR/cKIT | RTK | 2.2171 | -0.9803 | 0.2895 | 0.1040 | 2.2939 | 3.5791 | 0.96048 |
| MDA-MB-468 | Cediranib | VEGFR/cKIT | RTK | 3.9154 | -0.7083 | 0.1649 | 0.0970 | 3.0423 | 5.6183 | 0.9962 |
| HCC1419 | Cediranib | VEGFR/cKIT | RTK | 5.0599 | -0.0329 | 0.0545 | 0.0124 | 4.9952 | 5.1984 | 0.99032 |
| HCC1500 | Cediranib | VEGFR/cKIT | RTK | 3.8594 | -0.8084 | 0.1304 | 0.0735 | 3.4916 | 5.2864 | 0.99235 |
| MDA-MB-157 | Cediranib | VEGFR/cKIT | RTK | 0.82468 | -0.5845 | 0.3490 | 0.0876 | 0.8086 | 3.2088 | 0.96454 |
| BT-20 | Cediranib | VEGFR/cKIT | RTK | 5.6982 | 0.2210 | 0.0383 | 0.0150 | 2.7852 | 5.3221 | 0.97585 |
| HCC38 | Cediranib | VEGFR/cKIT | RTK | 1.5907 | -0.2044 | 0.2096 | 0.0416 | 1.0695 | 3.1564 | 0.98723 |
| MDA-MB-453 | Cediranib | VEGFR/cKIT | RTK | 2.7824 | -0.6894 | 0.1569 | 0.0768 | 3.0858 | 3.7659 | 0.99464 |
| HCC1395 | Cediranib | VEGFR/cKIT | RTK | 1.571 | -0.4825 | 0.2460 | 0.0671 | 1.0270 | 4.579 | 0.97022 |
| BT-549 | Cediranib | VEGFR/cKIT | RTK | 3.6412 | -0.1347 | 0.1497 | 0.0414 | 1.3011 | 8.4712 | 0.98092 |
| PDX1258 | Cediranib | VEGFR/cKIT | RTK | 4.7159 | -0.5611 | 0.0744 | 0.0681 | 4.9799 | 5.5703 | 0.99375 |
| HCC70 | Cediranib | VEGFR/cKIT | RTK | 4.5386 | -0.3262 | 0.0890 | 0.0440 | 2.2440 | 7.4053 | 0.99062 |
| PDX1328 | Cediranib | VEGFR/cKIT | RTK | 0.95412 | -0.8534 | 0.3764 | 0.0972 | 1.1127 | 2.5609 | 0.95134 |
| MDA-MB-134-VI | Cediranib | VEGFR/cKIT | RTK | 4.2103 | -0.9999 | 0.0977 | 0.0979 | 5.0000 | 5.2449 | 0.99321 |
| SK-BR-3 | Cediranib | VEGFR/cKIT | RTK | 6.1955 | -0.5397 | 0.0755 | 0.0528 | 4.8242 | 7.7773 | 0.99548 |
| Hs 578T | Cediranib | VEGFR/cKIT | RTK | 0.55083 | -0.5723 | 0.3937 | 0.1358 | 0.6641 | 2.8803 | 0.96002 |
| MDA-MB-231 | Cediranib | VEGFR/cKIT | RTK | 5.0964 | -0.3620 | 0.1160 | 0.0659 | 2.7537 | 7.595 | 0.99835 |
| MCF7 | Cediranib | VEGFR/cKIT | RTK | 5.7041 | 0.1149 | 0.0758 | 0.0191 | 1.5383 | 11.6508 | 0.98993 |
| MDA-MB-436 | Cediranib | VEGFR/cKIT | RTK | 3.6098 | -0.3824 | 0.1610 | 0.0446 | 1.8229 | 6.595 | 0.98039 |
| MCF 10A | Cediranib | VEGFR/cKIT | RTK | 9.6397 | 0.4781 | 0.0310 | 0.0012 | 3.3546 | 8.1 | 0.99825 |
| HCC1806 | Cediranib | VEGFR/cKIT | RTK | 4.9315 | 0.0954 | 0.0645 | 0.0363 | 4.9998 | 4.7786 | 0.98723 |
| CAL-120 | Cediranib | VEGFR/cKIT | RTK | 1.037 | -0.1243 | 0.2989 | 0.0564 | 0.5757 | 6.9922 | 0.99099 |
| HCC1954 | Cediranib | VEGFR/cKIT | RTK | 4.092 | -0.3202 | 0.0756 | 0.0534 | 4.9589 | 4.5507 | 0.99308 |