Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-231 Palbociclib
CDK4/6
Cell cycle
0.11065
 0.2066 0.3469 0.0101 0.7428
0.05699
0.98815
MDA-MB-231 AZD7762
CHK1/2
Cell cycle
0.15977
 -0.4632 0.5380 0.2422 0.9378
0.33846
0.98568
MCF7 Palbociclib
CDK4/6
Cell cycle
0.074952
 0.2542 0.3461 0.0139 1.0473
0.035667
0.99237
MDA-MB-231 Abemaciclib
CDK4/6
Cell cycle
0.046803
 -0.4875 0.6754 0.1393 0.3863
0.73058
0.97904
MCF 10A AZD7762
CHK1/2
Cell cycle
1.8064
 -0.1800 0.2246 0.0802 0.8472
6.6065
0.99793
MCF 10A Palbociclib
CDK4/6
Cell cycle
1.9503
 0.4544 0.1883 -0.0047 0.6492
0.23713
0.99244
MCF 10A Dinaciclib
pan CDK
Cell cycle
0.016244
 -0.2300 0.5279 0.2344 5.0000
0.017523
0.99904
MCF7 Abemaciclib
CDK4/6
Cell cycle
0.023572
 -0.2684 0.7018 0.0913 0.3795
0.13917
0.95433
MCF7 AZD7762
CHK1/2
Cell cycle
0.04144
 -0.1856 0.5977 0.1318 0.8993
0.048851
0.95892
MCF7 Dinaciclib
pan CDK
Cell cycle
0.0083068
 -0.2493 0.6441 0.1256 3.5461
0.009348
0.9995
Hs 578T Dinaciclib
pan CDK
Cell cycle
0.0089363
 -0.2388 0.6160 0.2121 4.9934
0.0096082
0.99916
Hs 578T Volasertib
PLK
Cell cycle
0.0025675
 -0.3123 0.8198 0.3337 3.0081
0.0029864
0.9987
HCC1806 Abemaciclib
CDK4/6
Cell cycle
0.59453
 -0.4440 0.3921 0.1035 0.6190
3.5069
0.96621
MCF 10A Abemaciclib
CDK4/6
Cell cycle
0.34027
 0.1513 0.3811 -0.0012 0.5714
0.28176
0.99756
HCC1806 Volasertib
PLK
Cell cycle
0.0027998
 -0.1323 0.7262 0.2950 5.0000
0.0029495
0.99776
MCF 10A Volasertib
PLK
Cell cycle
0.022128
 -0.0887 0.4466 0.1711 3.5358
0.023168
0.99997
HCC1806 Palbociclib
CDK4/6
Cell cycle
Inf
 0.6924 0.1460 0.0085 1.6543
0.024125
0.93749
Hs 578T AZD7762
CHK1/2
Cell cycle
0.015096
 -0.5983 0.8646 0.4133 1.8783
0.01967
0.95944
HCC1806 Dinaciclib
pan CDK
Cell cycle
0.013395
 -0.4585 0.6439 0.3114 3.4710
0.016174
0.99891
Hs 578T Palbociclib
CDK4/6
Cell cycle
0.15611
 0.3049 0.3195 0.0363 0.7223
0.037735
0.98196
MCF7 Volasertib
PLK
Cell cycle
0.0028671
 -0.0338 0.6070 0.1245 4.2176
0.002824
0.99423
Hs 578T Abemaciclib
CDK4/6
Cell cycle
0.077629
 -0.5825 0.6343 0.1966 0.4160
1.0889
0.95772
HCC1806 AZD7762
CHK1/2
Cell cycle
0.016629
 -0.4822 0.8897 0.3907 1.6771
0.023183
0.99277
MDA-MB-231 Dinaciclib
pan CDK
Cell cycle
0.010273
 -0.4203 0.6627 0.2555 2.6877
0.012709
0.99722
MDA-MB-231 Volasertib
PLK
Cell cycle
0.0043583
 -0.0186 0.5873 0.1359 3.6103
0.0044117
0.99795
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