Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAL-51 | A-1210477 | Mcl-1 | Misc | Inf | 0.9919 | 0.0073 | 0.0004 | 0.0000 | Inf | 0.00046652 |
| CAMA-1 | Alpelisib | PI3Ka | PI3K/mTOR | Inf | 0.9788 | 0.0106 | 0.0056 | 0.0000 | Inf | -0.0228 |
| MDA-MB-157 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.9754 | 0.0019 | 0.0010 | 0.0000 | Inf | 0.023059 |
| CAL-85-1 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9343 | -0.0283 | 0.0138 | 0.0000 | Inf | -0.025903 |
| BT-20 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.3900 | 0.5932 | 0.0889 | 0.0000 | Inf | 0.031152 |
| HCC70 | PF-4708671 | p70S6K | PI3K/mTOR | Inf | 0.9348 | -0.0227 | 0.0035 | 0.0000 | Inf | 0.040075 |
| MDA-MB-361 | A-1210477 | Mcl-1 | Misc | Inf | 0.9850 | -0.0083 | 0.0037 | 0.0000 | Inf | -0.045307 |
| HCC70 | Palbociclib | CDK4/6 | Cell cycle | Inf | 0.9361 | -0.0281 | -0.0013 | 0.0000 | Inf | -0.054738 |
| HME1 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.4888 | 0.3716 | 0.0206 | 0.0000 | Inf | 0.05647 |
| HCC38 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.4735 | 0.4865 | 0.0140 | 0.0000 | Inf | 0.060078 |
| BT-549 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9359 | -0.0225 | 0.0062 | 0.0000 | Inf | 0.067883 |
| MDA-MB-134-VI | Abemaciclib | CDK4/6 | Cell cycle | Inf | -0.9986 | 0.5722 | 0.0709 | 0.0000 | Inf | 0.086291 |
| SK-BR-3 | ABT-737 | Bcl2/XL | Misc | Inf | 0.9470 | -0.0148 | 0.0045 | 0.0000 | Inf | 0.12804 |
| HME1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0265 | -0.0318 | -0.0005 | 0.0000 | Inf | -0.12868 |
| PDX1328 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.2825 | 0.6902 | 0.0347 | 0.0000 | Inf | 0.15246 |
| HCC38 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9515 | -0.0246 | 0.0013 | 0.0000 | Inf | -0.17011 |
| HCC70 | A-1210477 | Mcl-1 | Misc | Inf | 0.9380 | 0.0054 | 0.0123 | 0.0000 | Inf | 0.17964 |
| HCC1806 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9819 | -0.0154 | 0.0035 | 0.0000 | Inf | -0.19348 |
| CAL-85-1 | A-1210477 | Mcl-1 | Misc | Inf | 1.0052 | 0.0109 | 0.0047 | 0.0000 | Inf | 0.20764 |
| MDA-MB-231 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9254 | 0.0073 | -0.0008 | 0.0000 | Inf | 0.28623 |
| HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
| HCC1500 | A-1210477 | Mcl-1 | Misc | Inf | 0.8719 | -0.0368 | 0.0081 | 0.0000 | Inf | 0.32761 |
| MDA-MB-453 | A-1210477 | Mcl-1 | Misc | Inf | 0.9330 | -0.0364 | 0.0157 | 0.0000 | Inf | -0.33803 |
| BT-549 | A-1210477 | Mcl-1 | Misc | Inf | 0.9540 | 0.0083 | 0.0018 | 0.0000 | Inf | 0.34182 |
| CAL-120 | A-1210477 | Mcl-1 | Misc | Inf | 0.9427 | 0.0152 | 0.0003 | 0.0000 | Inf | 0.34764 |