Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.6324 | 0.3348 | 0.0206 | 0.4211 | 0.00012787 | 0.92563 |
| MDA-MB-361 | Everolimus | mTOR1 | PI3K/mTOR | 0.00027478 | 0.0574 | 0.8497 | 0.0502 | 0.7979 | 0.00019313 | 0.7172 |
| SUM149PT | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.7389 | 0.2003 | 0.0098 | 0.2094 | 0.00021362 | 0.67353 |
| MDA-MB-134-VI | Everolimus | mTOR1 | PI3K/mTOR | 0.00017047 | -0.2444 | 1.1669 | 0.1034 | 0.5948 | 0.00034979 | 0.96485 |
| CAL-51 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.5477 | 0.4319 | 0.0326 | 1.0020 | 0.00038398 | 0.74949 |
| MDA-MB-436 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.6148 | 0.3144 | 0.0169 | 0.7543 | 0.00065027 | 0.85083 |
| HCC1428 | Everolimus | mTOR1 | PI3K/mTOR | 0.031039 | 0.3462 | 0.5186 | 0.0192 | 0.1000 | 0.0006981 | 0.70927 |
| MDA-MB-134-VI | Taxol | Chemo | Chemotherapy | 0.00012515 | -0.7183 | 1.3004 | 0.3511 | 0.5352 | 0.00075273 | 0.89205 |
| CAL-85-1 | Everolimus | mTOR1 | PI3K/mTOR | 0.0015471 | 0.3707 | 0.5762 | 0.0915 | 5.0000 | 0.0011149 | 0.86907 |
| HCC1500 | INK-128 | mTORC1/2 | PI3K/mTOR | 0.00078427 | -0.4693 | 1.2309 | 0.2717 | 1.2780 | 0.0013303 | 0.99127 |
| Hs 578T | Taxol | Chemo | Chemotherapy | 0.0010154 | -0.3752 | 0.9535 | 0.4788 | 1.2811 | 0.0015458 | 0.95438 |
| MCF7 | Taxol | Chemo | Chemotherapy | 0.0013771 | -0.1059 | 0.7722 | 0.1589 | 1.1560 | 0.0016261 | 0.94939 |
| HCC1806 | Taxol | Chemo | Chemotherapy | 0.0014225 | -0.2113 | 0.8398 | 0.3493 | 2.1569 | 0.0016621 | 0.96243 |
| HCC38 | Taxol | Chemo | Chemotherapy | 0.0014659 | -0.3078 | 0.8432 | 0.2758 | 2.3201 | 0.0017274 | 0.99328 |
| SUM149PT | Taxol | Chemo | Chemotherapy | 0.0015927 | -0.2583 | 0.8405 | 0.3816 | 3.1045 | 0.0017914 | 0.99574 |
| PDX1258 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.6306 | 0.3069 | 0.0224 | 0.5438 | 0.0017976 | 0.96445 |
| T47D | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0017858 | -0.1047 | 0.8990 | 0.0550 | 1.1740 | 0.0018197 | 0.97255 |
| CAL-120 | Volasertib | PLK | Cell cycle | 0.0018536 | 0.0258 | 0.6758 | 0.2649 | 2.5191 | 0.001844 | 0.99276 |
| HCC70 | Trametinib | MEK | MAPK/nRTK | 0.0019047 | -0.0393 | 0.6924 | 0.1954 | 0.8693 | 0.0021049 | 0.98467 |
| MCF 10A | Trametinib | MEK | MAPK/nRTK | 0.0033619 | 0.2252 | 0.5266 | -0.0015 | 1.2096 | 0.0021432 | 0.99763 |
| PDX1258 | Taxol | Chemo | Chemotherapy | 0.0021522 | -0.0818 | 0.6797 | 0.2357 | 1.2501 | 0.0022935 | 0.98829 |
| SUM159PT | Trametinib | MEK | MAPK/nRTK | 0.0055877 | 0.2792 | 0.4613 | 0.0039 | 0.9923 | 0.0023029 | 0.99862 |
| MDA-MB-453 | Taxol | Chemo | Chemotherapy | 0.002374 | 0.0356 | 0.6674 | 0.1683 | 1.2620 | 0.0023576 | 0.81734 |
| SK-BR-3 | Taxol | Chemo | Chemotherapy | 0.0019068 | -0.3401 | 0.8905 | 0.3665 | 2.3888 | 0.0023578 | 0.96349 |
| MDA-MB-468 | Taxol | Chemo | Chemotherapy | 0.001354 | -0.5218 | 1.0076 | 0.5243 | 1.2795 | 0.0023644 | 0.95471 |