Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
PDXHCI002 Everolimus
mTOR1
PI3K/mTOR
Inf
0.9869 -0.0453 -0.0479 0.0000
Inf
-4.5815
PDXHCI002 Bleomycin
Radiation
Misc
1.1636
-0.1199 0.2715 -0.0373 0.9659
2.0671
0.9892
PDXHCI002 INK-128
mTORC1/2
PI3K/mTOR
0.20621
0.2290 0.2366 -0.0367 1.3099
0.11357
0.97533
PDXHCI002 Etoposide
Topo II
Chemotherapy
0.18199
-0.1795 0.4902 -0.0311 1.1589
0.23962
0.98993
PDXHCI002 Cisplatin
Chemo
Chemotherapy
1.7306
-0.0985 0.2044 -0.0257 1.2874
2.4053
0.98631
CAL-51 Palbociclib
CDK4/6
Cell cycle
0.37241
0.3607 0.2498 -0.0215 0.8353
0.084749
0.99265
MDA-MB-134-VI Palbociclib
CDK4/6
Cell cycle
0.0092186
0.1787 0.5339 -0.0169 1.7301
0.0071324
0.98727
HCC1500 Bleomycin
Radiation
Misc
2.3381
0.1740 0.1688 -0.0166 1.0174
2.4596
0.98358
HCC1500 Etoposide
Topo II
Chemotherapy
1.4287
-0.0766 0.2499 -0.0148 1.3319
1.7871
0.95725
PDXHCI002 Palbociclib
CDK4/6
Cell cycle
0.12955
0.2766 0.2793 -0.0122 1.1851
0.053617
0.97783
PDXHCI002 Ipatasertib
AKT
PI3K/mTOR
Inf
1.0500 -0.0488 -0.0112 0.0000
Inf
-59.6281
HCC1500 Cisplatin
Chemo
Chemotherapy
3.4531
0.2076 0.1210 -0.0094 5.0000
3.1071
0.92762
HCC1500 Abemaciclib
CDK4/6
Cell cycle
0.53346
0.2196 0.3452 -0.0085 0.4860
0.1477
0.84102
HCC1954 Cabozantinib
VEGFR2/MET
RTK
10.9106
0.6390 -0.0135 -0.0074 5.0000
13.0234
0.87916
MDA-MB-134-VI Cisplatin
Chemo
Chemotherapy
10.3229
0.5019 0.0719 -0.0064 0.7594
36.1235
0.92643
HCC1954 PF-4708671
p70S6K
PI3K/mTOR
Inf
0.8349 -0.0093 -0.0064 1.3800
7.2097
0.65841
MDA-MB-134-VI Cabozantinib
VEGFR2/MET
RTK
10.9194
0.6362 -0.0167 -0.0063 5.0000
12.725
0.88168
CAL-120 TGX221
PI3Kb
PI3K/mTOR
Inf
1.0198 -0.0168 -0.0059 0.0000
Inf
-0.45144
HCC1419 Palbociclib
CDK4/6
Cell cycle
0.48725
0.4414 0.2239 -0.0054 1.2398
0.053717
0.97241
CAL-120 Everolimus
mTOR1
PI3K/mTOR
Inf
0.5275 0.4163 -0.0050 0.1797
1.1993e-05
0.81569
HCC1954 TGX221
PI3Kb
PI3K/mTOR
Inf
0.9607 -0.0374 -0.0050 0.0000
Inf
-1.0282
HCC1954 Palbociclib
CDK4/6
Cell cycle
Inf
0.5256 0.1839 -0.0048 1.2148
0.056374
0.97285
MCF 10A Palbociclib
CDK4/6
Cell cycle
1.9503
0.4544 0.1883 -0.0047 0.6492
0.23713
0.99244
CAL-85-1 Ipatasertib
AKT
PI3K/mTOR
Inf
0.4714 0.1662 -0.0047 1.3900
0.27338
0.96561
PDXHCI002 TGX221
PI3Kb
PI3K/mTOR
Inf
0.8545 -0.0204 -0.0045 5.0000
4.5889
0.61889
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