Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAL-51 | Ipatasertib | AKT | PI3K/mTOR | 2.978 | 0.3866 | 0.2238 | 0.0226 | 0.5898 | 0.68363 | 0.98798 |
| HCC1937 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.5349 | 0.1565 | 0.0058 | 1.0014 | 0.36202 | 0.97156 |
| MDA-MB-361 | Ipatasertib | AKT | PI3K/mTOR | 0.31325 | -0.5798 | 0.4548 | 0.0905 | 0.7404 | 1.2042 | 0.98932 |
| MDA-MB-468 | Ipatasertib | AKT | PI3K/mTOR | 2.3697 | 0.3091 | 0.2229 | 0.0266 | 0.5702 | 1.4742 | 0.96355 |
| HCC1419 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.5051 | 0.1071 | 0.0007 | 1.4251 | 0.82031 | 0.95841 |
| HCC1500 | Ipatasertib | AKT | PI3K/mTOR | Inf | 1.0500 | -0.0314 | -0.0045 | 0.0000 | Inf | -1.0541 |
| BT-549 | Ipatasertib | AKT | PI3K/mTOR | 12.6362 | 0.4956 | 0.1735 | 0.0097 | 0.5079 | 1.6786 | 0.97652 |
| MDA-MB-157 | Ipatasertib | AKT | PI3K/mTOR | 16.8543 | 0.5956 | 0.0813 | 0.0021 | 0.5783 | 112.0316 | 0.9146 |
| HCC38 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.7055 | 0.1225 | 0.0092 | 1.1410 | 0.22841 | 0.9721 |
| MDA-MB-453 | Ipatasertib | AKT | PI3K/mTOR | 0.53911 | -0.1551 | 0.3144 | 0.0753 | 1.3090 | 0.65666 | 0.98992 |
| HCC1395 | Ipatasertib | AKT | PI3K/mTOR | 0.93351 | 0.1903 | 0.2795 | 0.0199 | 0.6198 | 0.7738 | 0.97632 |
| MCF7 | Ipatasertib | AKT | PI3K/mTOR | 1.2964 | 0.2497 | 0.2597 | 0.0350 | 0.6498 | 0.91468 | 0.99756 |
| HCC70 | Ipatasertib | AKT | PI3K/mTOR | 0.1397 | -0.2624 | 0.4974 | 0.0860 | 0.8534 | 0.21677 | 0.98567 |
| PDX1258 | Ipatasertib | AKT | PI3K/mTOR | 4.4024 | 0.3985 | 0.1556 | 0.0120 | 0.7553 | 1.2185 | 0.94717 |
| MDA-MB-231 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9254 | 0.0073 | -0.0008 | 0.0000 | Inf | 0.28623 |
| MCF 10A | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.6472 | 0.0600 | -0.0019 | 1.0758 | 4.7959 | 0.99868 |
| PDX1328 | Ipatasertib | AKT | PI3K/mTOR | 4.7978 | 0.3012 | 0.1323 | 0.0153 | 0.6377 | 26.7942 | 0.95509 |
| MDA-MB-134-VI | Ipatasertib | AKT | PI3K/mTOR | 8.0392 | 0.4925 | 0.0150 | 0.0096 | 4.9968 | 3.7717 | 0.94642 |
| HCC1806 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9450 | 0.0145 | -0.0020 | 0.0000 | Inf | 0.32254 |
| Hs 578T | Ipatasertib | AKT | PI3K/mTOR | 4.5924 | 0.4423 | 0.2458 | 0.0093 | 0.5006 | 0.34659 | 0.98155 |
| BT-20 | Ipatasertib | AKT | PI3K/mTOR | 0.64483 | 0.1015 | 0.3111 | 0.0476 | 0.7459 | 0.59909 | 0.98219 |
| MDA-MB-436 | Ipatasertib | AKT | PI3K/mTOR | 25.8679 | 0.6111 | 0.1038 | 0.0116 | 0.4073 | 383.9431 | 0.92516 |
| SK-BR-3 | Ipatasertib | AKT | PI3K/mTOR | 3.3435 | 0.3560 | 0.1553 | 0.0254 | 0.8518 | 1.1231 | 0.9503 |
| CAL-120 | Ipatasertib | AKT | PI3K/mTOR | 58.682 | 0.5993 | 0.1297 | -0.0033 | 0.4437 | 5.6283 | 0.9635 |
| HCC1954 | Ipatasertib | AKT | PI3K/mTOR | 1.4342 | 0.2509 | 0.2145 | 0.0288 | 0.9249 | 0.80694 | 0.98539 |