Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | Saracatinib | SRC | MAPK/nRTK | Inf | 1.0500 | -0.0500 | 0.0181 | 0.0000 | Inf | -Inf |
| BT-549 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0401 | -0.0011 | 0.0000 | Inf | -9.2879 |
| MDA-MB-436 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0343 | -0.0002 | 0.0000 | Inf | -9.0203 |
| MDA-MB-231 | A-1210477 | Mcl-1 | Misc | Inf | 0.9569 | 0.0519 | 0.0034 | 0.0000 | Inf | -8.5977e-09 |
| BT-20 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0152 | -0.0415 | -0.0034 | 0.0000 | Inf | -7.4504 |
| PDXHCI002 | Ipatasertib | AKT | PI3K/mTOR | Inf | 1.0500 | -0.0488 | -0.0112 | 0.0000 | Inf | -59.6281 |
| CAL-85-1 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0418 | -0.0009 | 0.0000 | Inf | -4.681 |
| HCC1937 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0500 | -0.0406 | -0.0017 | 0.0000 | Inf | -4.6521 |
| PDXHCI002 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.9869 | -0.0453 | -0.0479 | 0.0000 | Inf | -4.5815 |
| SUM149PT | TGX221 | PI3Kb | PI3K/mTOR | Inf | 1.0138 | -0.0216 | 0.0006 | 0.0000 | Inf | -4.4171 |
| MDA-MB-134-VI | A-1210477 | Mcl-1 | Misc | Inf | 1.0500 | -0.0366 | -0.0033 | 0.0000 | Inf | -3.0589 |
| HCC1806 | Everolimus | mTOR1 | PI3K/mTOR | Inf | 0.8168 | 0.1972 | 0.0004 | 0.0000 | Inf | -2.9998e-08 |
| HCC1428 | Ipatasertib | AKT | PI3K/mTOR | Inf | 0.9911 | -0.0383 | -0.0001 | 0.0000 | Inf | -2.9826 |
| PDX1258 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9970 | -0.0328 | 0.0026 | 0.0000 | Inf | -2.2747 |
| PDXHCI002 | A-1210477 | Mcl-1 | Misc | Inf | 0.9814 | -0.0380 | 0.0049 | 0.0000 | Inf | -2.2577 |
| PDX1258 | Palbociclib | CDK4/6 | Cell cycle | Inf | 1.0159 | -0.0479 | 0.0014 | 0.0000 | Inf | -18.593 |
| HCC1500 | Ipatasertib | AKT | PI3K/mTOR | Inf | 1.0500 | -0.0314 | -0.0045 | 0.0000 | Inf | -1.0541 |
| HCC1954 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9607 | -0.0374 | -0.0050 | 0.0000 | Inf | -1.0282 |
| CAL-85-1 | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.9895 | -0.0309 | 0.0002 | 0.0000 | Inf | -1.0218 |
| MCF 10A | Volasertib | PLK | Cell cycle | 0.022128 | -0.0887 | 0.4466 | 0.1711 | 3.5358 | 0.023168 | 0.99997 |
| MCF 10A | INK-128 | mTORC1/2 | PI3K/mTOR | 0.024199 | 0.1716 | 0.4673 | -0.0027 | 1.3149 | 0.017581 | 0.99992 |
| MCF 10A | Luminespib | HSP90 | Misc | 0.0076226 | -0.1717 | 0.6131 | 0.2622 | 3.1403 | 0.0083878 | 0.9999 |
| MCF 10A | Vorinostat | HDAC | Misc | 2.5293 | 0.0566 | 0.1675 | 0.0065 | 1.2709 | 3.1489 | 0.99982 |
| MDA-MB-468 | Vorinostat | HDAC | Misc | 1.5734 | -0.1191 | 0.2172 | 0.0608 | 1.9840 | 1.8053 | 0.99971 |
| SUM159PT | Luminespib | HSP90 | Misc | 0.0063084 | -0.0476 | 0.5743 | 0.2156 | 4.5596 | 0.0064127 | 0.9997 |