Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 7808.043 | uM | 3.95580 | 3.81630 | -0.1647 | 0.0821 | 5.0000 | 0.2428 | 0.8707 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 7808.052 | uM | inf | 0.72086 | 0.5882 | 0.6283 | 0.8496 | 0.1837 | 0.9560 | 2.4842 | ||
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 9226.021 | uM | 8.73650 | 13.53040 | -0.6894 | -0.7018 | 2.0049 | 0.3883 | 0.9995 | 2.5142 | |
| HBL-100 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7429.074 | uM | 0.21399 | 0.25848 | -0.7951 | -0.7656 | 4.9167 | 0.8819 | 0.9981 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7807.042 | uM | inf | inf | 1.0098 | 1.0098 | 0.0000 | -0.0392 | -7.7987 | 2.0250 | |
| HBL-100 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 9226.034 | uM | 747.89280 | 1000.00000 | -0.4886 | -0.3587 | 1.8615 | 0.2518 | 0.7818 | 2.6175 | ||
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7807.017 | uM | inf | inf | -0.4695 | -0.4695 | 0.0000 | 0.2218 | 0.4545 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7808.017 | uM | 10.81030 | 17.89770 | -0.9142 | -0.9247 | 2.0769 | 0.3820 | 0.9981 | 2.4168 | |
| HBL-100 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7807.017 | uM | 112.83770 | 154.79750 | -0.0609 | -0.0980 | 0.5660 | 0.4078 | 0.9916 | 2.2007 | |
| HBL-100 | Unknown | Unknown | AG1478 | EGFR | ErbB | 7807.016 | uM | inf | inf | 0.9359 | 0.9359 | 0.0000 | 0.0541 | 0.4439 | 2.1516 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7807.011 | uM | 80.29730 | 142.76360 | -0.7730 | -0.8163 | 1.6820 | 0.3238 | 0.9983 | 2.1620 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 9226.021 | uM | 62.75020 | 112.42070 | -0.7415 | -0.7713 | 1.6005 | 0.3338 | 0.9996 | 2.5142 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7429.102 | uM | inf | 0.00269 | 0.9697 | 0.9727 | 4.9973 | 0.0039 | 0.6691 | 2.4347 | |
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7807.04 | uM | 1.67060 | 4.14870 | -0.7759 | -0.7682 | 1.0232 | 0.4211 | 0.9891 | 2.1435 | |
| HBL-100 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7429.074 | uM | 0.21399 | 0.25848 | -0.7951 | -0.7656 | 4.9167 | 0.8819 | 0.9981 | 2.3375 | |
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 7807.016 | uM | 11.62140 | 15.50560 | -0.8212 | -0.8219 | 3.3715 | 0.3669 | 0.9974 | 2.1516 | ||
| HBL-100 | Unknown | Unknown | (Z)-4-Hydroxytamoxifen | ESR1 | 7808.016 | uM | inf | 13.19490 | 0.5274 | 0.7135 | 4.9687 | 0.0363 | 0.6432 | 2.2401 | ||
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7808.05 | uM | 0.95232 | 1.51340 | -0.4445 | -0.4552 | 1.3976 | 0.4994 | 0.9942 | 2.5177 | |
| HBL-100 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7808.017 | uM | 153.52750 | 267.86840 | -0.0890 | -0.1730 | 0.5339 | 0.3993 | 0.9832 | 2.4168 | |
| HBL-100 | Unknown | Unknown | AG1024 | IGF1R | RTK | 7429.066 | uM | inf | inf | 0.9919 | 0.9919 | 0.0000 | 0.0080 | 0.0137 | 2.3904 | |
| HBL-100 | Unknown | Unknown | AG1478 | EGFR | ErbB | 7808.016 | uM | inf | inf | 0.9515 | 0.9515 | 0.0000 | -0.0168 | 0.0597 | 2.2401 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7808.011 | uM | 91.64120 | 178.22410 | -0.9131 | -0.9831 | 1.6346 | 0.3085 | 0.9967 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 7807.002 | uM | 0.00197 | 0.00179 | 0.2403 | 0.1261 | 3.1066 | 0.6084 | 0.9293 | 2.1668 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 9226.034 | uM | 2.78310 | 4.5530 | -0.6561 | -0.6763 | 1.7380 | 0.3659 | 0.9993 | 2.6175 |