Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	Nutlin 3a	MDM2	MDM2	5895.066	uM	3.22280	10.22950	-0.9725	-1.0000	0.9512	0.3133	0.9559	1.1612
184A1	NM	Basal	Oxamflatin	HDAC	HDAC	12509.147	uM	1.65310	3.49760	-0.9533	-1.0000	1.4659	0.4736	0.9918	1.2058
184A1	NM	Basal	NU6102	CDK1/2	CDK	12509.147	uM	6.59190	12.95280	-0.8721	-1.0000	1.6264	0.2474	0.9935	1.2058
184A1	NM	Basal	Nutlin 3a	MDM2	MDM2	5894.066	uM	6.76640	16.58460	-0.8949	-1.0000	1.2254	0.2778	0.9387	1.5027
184A1	NM	Basal	Oxaliplatin	DNA cross-linker	DNA cross-linker	9047.011	uM	0.53932	2.18460	-0.9996	-1.0000	0.7854	0.8887	0.9928	0.6293
184A1	NM	Basal	Oxaliplatin	DNA cross-linker	DNA cross-linker	10002.021	uM	1.98010	5.92780	-0.9908	-1.0000	1.0019	0.7527	0.9764	0.7195
184A1	NM	Basal	Imatinib	ABL/KIT/PDGFR	nRTK	5895.091	uM	16.09010	26.49230	-0.9899	-1.0000	2.2032	0.4630	0.9969	1.1729
184A1	NM	Basal	L-779450	BRAF	MAPK	12509.166	uM	8.56520	14.40640	-0.7107	-1.0000	2.1129	0.1672	0.9687	1.2847
184A1	NM	Basal	Gemcitabine	DNA replication	DNA replication	9047.011	uM	0.39288	3.58790	-0.7197	-1.0000	0.4967	0.6665	0.9520	0.6293
184A1	NM	Basal	IKK16	IKK	NFKB	5895.093	uM	1.01110	2.37210	-0.9564	-1.0000	1.2884	0.5085	0.9882	1.3259
184A1	NM	Basal	Ixabepilone	TUBB	TUBB	5895.095	uM	0.14338	0.76637	-0.9501	-1.0000	0.6554	0.6829	0.9483	1.4629
184A1	NM	Basal	GSK461364	PLK1	PLK	10002.001	uM	6.06620	9.11620	-0.9717	-1.0000	2.6972	0.2605	0.9735	0.5372
184A1	NM	Basal	GSK923295	CENPE	Kinesin	10002.001	uM	8.47170	11.6240	-0.9507	-1.0000	3.4729	0.2407	0.9439	0.5372
184A1	NM	Basal	Etoposide	TOP2	TOP	5894.074	uM	9.28560	35.69030	-0.7680	-1.0000	0.8160	0.4044	0.9826	1.4541
184A1	NM	Basal	Etoposide	TOP2	TOP	5895.074	uM	10.48650	42.19930	-0.7395	-1.0000	0.7891	0.3710	0.9859	1.1218
184A1	NM	Basal	Everolimus	MTOR	MTOR	12509.164	uM	0.02317	2.80470	-0.9610	-1.0000	0.2291	0.6861	0.6516	1.1949
184A1	NM	Basal	Ispinesib	KSP	Kinesin	5894.067	uM	1.62180	3.48940	-0.9288	-1.0000	1.4339	0.3983	0.9581	1.5647
184A1	NM	Basal	CGC-11047	Polyamine analogue		10002.034	uM	242.78660	399.08510	-0.9907	-1.0000	2.2105	0.6269	0.7996	0.6736
184A1	NM	Basal	CGC-11047	Polyamine analogue		9047.026	uM	5.67110	70.62780	-0.9997	-1.0000	0.4356	0.7516	0.8174	0.5972
184A1	NM	Basal	Afatinib	EGFR/HER2	ErbB	12509.165	uM	0.02251	0.33740	-0.9088	-1.0000	0.4058	0.8284	0.9307	1.5022
184A1	NM	Basal	GSK461364	PLK1	PLK	9047.001	uM	4.15810	52.44110	-0.0073	-1.0000	0.4334	0.2620	0.7464	0.7701
184A1	NM	Basal	Ibandronate	FDPS		12509.143	uM	155.22840	288.34070	-0.9140	-1.0000	1.7741	0.2785	0.9964	1.3392
184A1	NM	Basal	Ispinesib	KSP	Kinesin	5895.067	uM	2.25070	4.57410	-0.9091	-1.0000	1.5491	0.3497	0.9692	1.4053
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)