Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HBL-100 | Unknown | Unknown | Pertuzumab | 7429.102 | mg/ml | inf | 0.21142 | 0.9391 | 0.9176 | 0.6095 | 0.0085 | 0.7039 | 2.4347 | |||
HCC1428 | HR+ | Luminal | Pertuzumab | 7441.102 | mg/ml | inf | inf | 0.9063 | 0.9063 | 0.0000 | 0.0249 | 0.2346 | 0.9144 | |||
MCF 10F | NM | - | Pertuzumab | 7487.102 | mg/ml | inf | 124.94960 | 0.6533 | -0.1750 | 0.2135 | 0.1284 | 0.7894 | 1.5273 | |||
BT-20 | TNBC | Basal A | Pertuzumab | 5903.102 | mg/ml | inf | inf | 0.9324 | 0.9324 | 0.0000 | -0.0074 | -0.0405 | 1.2557 | |||
HCC1569 | HER2amp | Basal A | Pertuzumab | 7447.102 | mg/ml | inf | 124.99960 | 0.8861 | 0.6968 | 0.1346 | 0.0581 | 0.6369 | 1.6467 | |||
MCF12A | NM | Basal B | Pertuzumab | 7489.102 | mg/ml | inf | 125.00000 | 0.8728 | 0.5007 | 0.2455 | 0.0447 | 0.7417 | 2.4234 | |||
184A1 | NM | Basal | AG1024 | IGF1R | RTK | 5895.066 | uM | 0.19048 | 0.25224 | -0.2007 | -0.1853 | 1.1224 | 0.4351 | 0.9959 | 1.1612 | |
184A1 | NM | Basal | AG1024 | IGF1R | RTK | 5894.066 | uM | 0.20895 | 0.19857 | 0.0442 | 0.1124 | 5.0000 | 0.3444 | 0.9895 | 1.5027 | |
184A1 | NM | Basal | 5-DFUR | TYMS | TYMS | 12509.143 | uM | 228.63720 | 1000.00000 | -0.2404 | -0.6424 | 0.5600 | 0.2642 | 0.9697 | 1.3392 | |
184A1 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5895.074 | uM | 0.02162 | 0.11251 | -0.8342 | -0.8244 | 0.5906 | 1.0107 | 0.9534 | 1.1218 | |
184A1 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5894.074 | uM | 0.03715 | 0.13270 | -0.6899 | -0.6765 | 0.6722 | 0.9059 | 0.9559 | 1.4541 | |
184A1 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5894.074 | uM | 0.03715 | 0.13270 | -0.6899 | -0.6765 | 0.6722 | 0.9059 | 0.9559 | 1.4541 | |
184A1 | NM | Basal | Bosutinib | Src | nRTK | 12509.17 | uM | 0.45547 | 0.47009 | -0.0739 | -0.0269 | 1.6575 | 0.3664 | 0.9494 | 1.3955 | |
184A1 | NM | Basal | Carboplatin | DNA cross-linker | DNA cross-linker | 9047.011 | uM | 9.5630 | 14.41690 | -0.9873 | -0.8900 | 2.4907 | 0.7356 | 0.9439 | 0.6293 | |
184A1 | NM | Basal | Bortezomib | Proteasome | Proteasome | 5895.074 | uM | 0.02162 | 0.11251 | -0.8342 | -0.8244 | 0.5906 | 1.0107 | 0.9534 | 1.1218 | |
184A1 | NM | Basal | Afatinib | EGFR/HER2 | ErbB | 12509.165 | uM | 0.02251 | 0.33740 | -0.9088 | -1.0000 | 0.4058 | 0.8284 | 0.9307 | 1.5022 | |
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 10002.034 | uM | 242.78660 | 399.08510 | -0.9907 | -1.0000 | 2.2105 | 0.6269 | 0.7996 | 0.6736 | ||
184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 9047.026 | uM | 0.00360 | 0.01403 | -0.2605 | -0.4617 | 0.4805 | 0.4918 | 0.8777 | 0.5972 | |
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 9047.026 | uM | 5.67110 | 70.62780 | -0.9997 | -1.0000 | 0.4356 | 0.7516 | 0.8174 | 0.5972 | ||
184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 7787.018 | uM | 839.83530 | 1000.00000 | -0.8398 | -0.6967 | 5.0000 | 0.2577 | 0.8874 | 0.3791 | ||
184A1 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 9047.017 | uM | 2.85670 | 3.92150 | -0.9940 | -0.8307 | 3.0896 | 0.5793 | 0.9882 | 0.8440 | |
184A1 | NM | Basal | Cisplatin | DNA cross-linker | DNA cross-linker | 10002.021 | uM | 2.61470 | 4.77760 | -0.9719 | -0.9559 | 1.7730 | 0.6305 | 0.9959 | 0.7195 | |
184A1 | NM | Basal | CPT-11 | TOP1 | TOP | 9047.121 | uM | 3.33380 | 6.76440 | -0.6694 | -0.7837 | 1.3326 | 0.4789 | 0.9103 | 0.7949 | |
184A1 | NM | Basal | Baicalein | Lipoxygenase | Metabolism | 5895.073 | uM | inf | 35.38250 | 0.5990 | 0.5817 | 2.0246 | 0.0235 | 0.9408 | 1.4431 | |
184A1 | NM | Basal | Cetuximab | EGFR | ErbB | 7787.018 | uM | inf | inf | 0.4652 | 0.4652 | 0.0000 | 0.3838 | -0.0013 | 0.3791 |