Bortezomib - Small Molecule (ID:10241-101)

HMS LINCS ID: 10241-101
Name: Bortezomib
Alternative Names: Velcade
LINCS ID: LSM-6281
PubChem CID: 387447
ChEBI ID:
ChEMBL ID:
Molecular Mass: 384.20
InChi: InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChi Key: GXJABQQUPOEUTA-RDJZCZTQSA-N
SMILES: B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
NFKB1, NFKB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB1, PSMB10, PSMB11, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9, RELA
2
(equivalent to 100 nM ≤ Kd < 1µM)
CTRB1, CTSG, PSMB2
3
(equivalent to 1µM ≤ Kd < 10 µM)
CMA1, CTSA, ELANE
10
(confirmed non-binding)

Batch Information for HMSL10241-101-1:

HMS LINCS Batch ID: 10241-101-1
Provider: LC Laboratories
Provider Batch ID:
Salt: 101
Molecular Formula: C19H25BN4O4
Molecular Weight: 384.24
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2012-11-14
Most Recent Update: 2016-12-02