Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC1428
HR+
Luminal
Nilotinib
ABL
nRTK
11936.145
uM
inf
2.17830
0.5045 0.5364 5.0000 0.1750
0.8994
0.8451
HCC1806
TNBC
Basal A
Nilotinib
ABL
nRTK
12239.145
uM
inf
inf
0.9597 0.9597 0.0000 0.0201
-0.0222
2.1348
HCC1143
TNBC
Basal A
Nilotinib
ABL
nRTK
12112.145
uM
inf
inf
0.9353 0.9353 0.0000 0.0338
0.0179
1.9247
HCC1428
HR+
Luminal
Nilotinib
ABL
nRTK
10693.145
uM
13.06880
9.64330
0.2012 0.3906 5.0000 0.1556
0.8568
0.8492
HCC1569
HER2amp
Basal A
Nilotinib
ABL
nRTK
10872.145
uM
inf
inf
1.0423 1.0423 0.0000 0.0067
0.0000
1.6308
HCC1569
HER2amp
Basal A
Nilotinib
ABL
nRTK
12523.17
uM
inf
inf
0.8636 0.8636 0.0000 0.0444
0.0000
0.8990
BT-549
TNBC
Basal B
Nilotinib
ABL
nRTK
12305.17
uM
inf
1.80680
0.8403 0.8115 4.9996 0.0758
0.8551
2.7728
CAMA-1
HR+
Luminal
Nilotinib
ABL
nRTK
10755.145
uM
inf
inf
0.9059 0.9059 0.0000 0.0960
0.1467
0.7688
HCC1395
TNBC
Basal B
Nilotinib
ABL
nRTK
12000.145
uM
inf
inf
1.0500 1.0500 0.0000 0.0614
0.0000
0.6084
HCC1395
TNBC
Basal B
Nilotinib
ABL
nRTK
12084.145
uM
inf
2.91120
0.7469 0.7472 5.0000 0.0902
0.9079
1.1692
BT-483
HR+
Luminal
Nilotinib
ABL
nRTK
10696.145
uM
inf
inf
0.6817 0.6817 0.0000 0.2546
0.0751
0.3316
AU565
HER2amp
Luminal
Nilotinib
ABL
nRTK
10880.145
uM
inf
inf
0.9804 0.9804 0.0000 0.0621
0.0247
1.4751
BT-474
HER2amp
Luminal
Nilotinib
ABL
nRTK
12178.145
uM
inf
inf
1.0500 1.0500 0.0000 0.0369
0.0948
0.6127
BT-474
HER2amp
Luminal
Nilotinib
ABL
nRTK
12056.145
uM
inf
inf
0.9538 0.9538 0.0000 0.0958
0.3538
0.8365
BT-483
HR+
Luminal
Nilotinib
ABL
nRTK
11855.145
uM
inf
inf
0.3444 0.3444 0.0000 0.3027
0.5178
0.5070
BT-474
HER2amp
Luminal
Nilotinib
ABL
nRTK
12291.17
uM
inf
inf
0.6458 0.6458 0.0000 0.2392
0.3142
0.5585
184A1
NM
Basal
Nilotinib
ABL
nRTK
12509.17
uM
inf
0.16976
0.8260 0.8615 1.0340 0.0781
0.8007
1.3955
CAMA-1
HR+
Luminal
Nilotinib
ABL
nRTK
12070.145
uM
inf
inf
0.8990 0.8990 0.0000 0.1345
0.0301
1.0737
BT-20
TNBC
Basal A
Nilotinib
ABL
nRTK
11854.145
uM
inf
7.90530
0.4616 0.5489 5.0000 0.1255
0.8664
1.1581
HCC1187
TNBC
Basal A
Nilotinib
ABL
nRTK
10753.145
uM
410.88640
1000.00000
0.5140 -0.1122 0.2277 0.1893
0.7339
1.5180
184B5
NM
Basal
Nilotinib
ABL
nRTK
12566.17
uM
inf
0.08710
0.9223 0.9254 0.8046 0.0464
0.8541
1.4648
BT-20
TNBC
Basal A
Nilotinib
ABL
nRTK
10581.145
uM
16.74520
10.16160
0.3643 0.3665 2.6440 0.1747
0.9485
0.9044
600MPE
HR+
Luminal
Nilotinib
ABL
nRTK
12224.145
uM
inf
inf
0.9894 0.9894 0.0000 -0.0249
-0.6099
0.9737
HCC1954
HER2amp
Basal A
Nilotinib
ABL
nRTK
11055.145
uM
inf
inf
0.9791 0.9791 0.0000 -0.0257
-0.8188
1.7616
HCC1937
TNBC
Basal A
Nilotinib
ABL
nRTK
11849.145
uM
inf
inf
1.0500 1.0500 0.0000 0.0324
0.0000
1.5253
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