Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7807.04 | uM | 1.67060 | 4.14870 | -0.7759 | -0.7682 | 1.0232 | 0.4211 | 0.9891 | 2.1435 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7813.037 | uM | 1.13960 | 2.30350 | -0.5356 | -0.4451 | 0.9048 | 0.3852 | 0.9661 | 0.7127 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 10261.037 | uM | 0.02633 | 0.02899 | -0.7748 | -0.3082 | 5.0000 | 0.7926 | 0.9233 | 2.1973 | |
| HCC1143 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7810.037 | uM | 0.10847 | 0.11854 | -0.5893 | -0.2795 | 4.9996 | 0.6702 | 0.9570 | 1.0223 | |
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7811.04 | uM | 1.04690 | 1.38930 | -1.0000 | -0.9258 | 3.7023 | 0.7792 | 0.8482 | 0.3921 | |
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7812.04 | uM | 4.6730 | 5.92090 | -0.2506 | -0.2552 | 1.7425 | 0.3049 | 0.9762 | 1.0573 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9163.037 | uM | 0.02296 | 0.02797 | -0.9651 | -0.8419 | 4.9994 | 1.1656 | 0.9949 | 0.5258 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9186.037 | uM | 0.14337 | 1.08130 | -0.9871 | -1.0000 | 0.5437 | 0.6949 | 0.9553 | 0.5199 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7805.05 | uM | 0.33059 | 0.62314 | -0.2532 | -0.2197 | 0.5745 | 0.4652 | 0.9470 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9210.037 | uM | 0.17414 | 0.82088 | -0.7513 | -0.7575 | 0.5948 | 0.6396 | 0.9590 | 0.8166 | |
| HCC1143 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 9233.037 | uM | 0.13452 | 0.14749 | -0.6831 | -0.2923 | 4.9987 | 0.6200 | 0.9412 | 1.2235 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7793.037 | uM | 0.05319 | 0.09484 | -0.5860 | -0.4080 | 1.0317 | 0.7361 | 0.9655 | 1.0948 | |
| AU565 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9146.037 | uM | 0.15634 | 3.69020 | -0.9186 | -1.0000 | 0.3475 | 0.5819 | 0.8060 | 1.2617 | |
| HBL-100 | Unknown | Unknown | 17-AAG | HSP90 | HSP90 | 7808.05 | uM | 0.95232 | 1.51340 | -0.4445 | -0.4552 | 1.3976 | 0.4994 | 0.9942 | 2.5177 | |
| 184A1 | NM | Basal | 17-AAG | HSP90 | HSP90 | 9047.037 | uM | 0.00930 | 0.01282 | -0.9826 | -0.6989 | 2.7212 | 1.1760 | 0.9539 | 0.5262 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9118.037 | uM | 0.04887 | 0.06801 | -0.6590 | -0.2633 | 1.2803 | 0.6962 | 0.9129 | 1.0733 | |
| BT-474 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9158.037 | uM | 0.01213 | 0.01343 | -0.1754 | -0.3299 | 4.9817 | 0.9735 | 0.6470 | 0.4702 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7801.037 | uM | 0.10644 | 0.52164 | -0.9762 | -0.9265 | 0.6596 | 0.7616 | 0.9437 | 0.3490 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9024.05 | uM | 0.02921 | 0.03286 | -0.1856 | -0.1216 | 1.8477 | 0.7101 | 0.9907 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7804.04 | uM | 0.03781 | 0.04034 | -0.3858 | -0.1912 | 4.9993 | 0.6899 | 0.9760 | 2.5402 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7791.05 | uM | 0.19521 | 5.16170 | -0.6281 | -0.9627 | 0.3278 | 0.5521 | 0.8525 | 0.7929 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7803.04 | uM | 0.04213 | 0.04438 | -0.2512 | -0.1490 | 4.9962 | 0.6704 | 0.9919 | 2.8752 | |
| 184B5 | NM | Basal | 17-AAG | HSP90 | HSP90 | 9095.037 | uM | 0.02221 | 0.02925 | -0.9385 | -0.7659 | 3.3756 | 1.0941 | 0.9910 | 1.0013 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7814.04 | uM | 0.08640 | 0.24294 | -0.6919 | -0.5378 | 0.7063 | 0.7010 | 0.9709 | 0.8711 | |
| HCC1395 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9254.037 | uM | 0.19480 | 0.66652 | -0.5117 | -0.5396 | 0.5950 | 0.5855 | 0.9698 | 0.8345 |