Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10753.15 | uM | 0.49239 | 0.52921 | -0.1737 | -0.1339 | 3.2903 | 0.3927 | 0.9860 | 1.4129 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10693.15 | uM | 6.71360 | 20.13110 | -0.2575 | -1.0000 | 1.0004 | 0.1570 | 0.9873 | 0.7763 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10473.138 | uM | inf | 0.52667 | 0.7059 | 0.7725 | 1.9365 | 0.1088 | 0.7415 | 1.2872 | |
| HCC1187 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10518.138 | uM | 0.23611 | 0.23002 | 0.0120 | 0.0612 | 5.0000 | 0.4780 | 0.9213 | 1.3413 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12001.169 | uM | 3.57110 | 22.85030 | -0.2400 | -1.0000 | 0.5919 | 0.2981 | 0.9468 | 0.7194 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 11936.16 | uM | inf | inf | 0.3250 | 0.3250 | 0.0000 | 0.2837 | 0.5167 | 0.8962 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10696.15 | uM | inf | inf | 0.4427 | 0.4427 | 0.0000 | 0.1816 | 0.5138 | 0.4740 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10755.15 | uM | inf | inf | 0.3961 | 0.3961 | 0.0000 | 0.3344 | 0.2163 | 0.7807 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 12070.16 | uM | 1.57910 | 13.1750 | -0.8353 | -1.0000 | 0.5179 | 0.4318 | 0.8564 | 0.8453 | |
| HCC1143 | TNBC | Basal A | ZM-447439 | AURK | AURK | 12112.16 | uM | 2.1830 | 0.50095 | 0.4358 | 0.4738 | 2.0026 | 0.2316 | 0.9687 | 1.7073 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12084.16 | uM | 10.36280 | 49.94910 | -0.3937 | -1.0000 | 0.6985 | 0.2339 | 0.8776 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12000.169 | uM | 1.98770 | 4.28150 | -0.8539 | -0.9196 | 1.3600 | 0.4011 | 0.9959 | 0.8565 | |
| 184A1 | NM | Basal | ZM-447439 | AURK | AURK | 12509.169 | uM | inf | 1.20210 | 0.5422 | 0.5277 | 0.9240 | 0.1592 | 0.9369 | 1.5064 | |
| 184B5 | NM | Basal | ZM-447439 | AURK | AURK | 12566.169 | uM | inf | 0.69572 | 0.6262 | 0.6434 | 1.3748 | 0.1369 | 0.9197 | 1.6359 | |
| 600MPE | HR+ | Luminal | ZM-447439 | AURK | AURK | 12224.16 | uM | inf | 0.71576 | 0.5232 | 0.6757 | 4.9996 | 0.1273 | 0.7131 | 0.7734 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12291.169 | uM | 2.74420 | 2.49370 | -0.0499 | 0.1902 | 5.0000 | 0.2447 | 0.7269 | 0.3548 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12178.16 | uM | inf | inf | 0.5577 | 0.5577 | 0.0000 | 0.3142 | 0.4077 | 0.7392 | |
| BT-549 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12305.169 | uM | 2.99320 | 2.80590 | 0.0176 | 0.1380 | 5.0000 | 0.1621 | 0.9692 | 2.5786 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10581.138 | uM | 5.16160 | 30.74760 | -0.4765 | -1.0000 | 0.6156 | 0.3418 | 0.9196 | 0.9462 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 11855.16 | uM | inf | inf | 0.5429 | 0.5429 | 0.0000 | 0.3123 | 0.0079 | 0.6477 | |
| BT-474 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12056.16 | uM | 18.20560 | 49.54740 | -0.4446 | -1.0000 | 1.0973 | 0.3126 | 0.7841 | 0.9124 | |
| BT-20 | TNBC | Basal A | ZM-447439 | AURK | AURK | 11854.16 | uM | 7.8450 | 6.64530 | 0.3364 | 0.0291 | 0.3615 | 0.2804 | 0.8971 | 1.3102 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10880.15 | uM | inf | 0.49203 | 0.4211 | 0.5508 | 2.4406 | 0.1717 | 0.8585 | 1.5829 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 12523.169 | uM | 2.07870 | 2.01410 | 0.0185 | 0.0731 | 5.0000 | 0.2305 | 0.9846 | 1.0498 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 10872.15 | uM | inf | 0.35621 | 0.5700 | 0.5657 | 1.8837 | 0.1901 | 0.8828 | 1.6255 |