Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | CAL-101 | 3 | 72 | 3.2 | 2028.8 | 2946.5 | 517.3 | 0.505 | 0.724 | 0.689 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.001 | 2230.0 | 2731.3 | 517.3 | -3.0 | 0.838 | 0.816 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.0032 | 2166.5 | 2731.3 | 517.3 | -2.49 | 0.816 | 0.793 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.01 | 2209.0 | 2731.3 | 517.3 | -2.0 | 0.831 | 0.809 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.032 | 2167.0 | 2731.3 | 517.3 | -1.49 | 0.816 | 0.793 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.1 | 2178.5 | 2731.3 | 517.3 | -1.0 | 0.820 | 0.798 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.32 | 2018.3 | 2731.3 | 517.3 | -0.495 | 0.763 | 0.739 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 1.0 | 2109.5 | 2731.3 | 517.3 | 0.0 | 0.796 | 0.772 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 3.2 | 1979.8 | 2731.3 | 517.3 | 0.505 | 0.749 | 0.725 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.001 | 2889.0 | 2827.0 | 517.3 | -3.0 | 1.020 | 1.020 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.0032 | 3088.5 | 2827.0 | 517.3 | -2.49 | 1.070 | 1.090 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.01 | 2986.0 | 2827.0 | 517.3 | -2.0 | 1.050 | 1.060 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.032 | 2930.3 | 2827.0 | 517.3 | -1.49 | 1.030 | 1.040 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.1 | 2809.0 | 2827.0 | 517.3 | -1.0 | 0.995 | 0.994 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.32 | 2468.3 | 2827.0 | 517.3 | -0.495 | 0.892 | 0.873 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 1.0 | 1619.0 | 2827.0 | 517.3 | 0.0 | 0.593 | 0.573 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 3.2 | 992.8 | 2827.0 | 517.3 | 0.505 | 0.305 | 0.351 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.001 | 2859.8 | 2773.8 | 517.3 | -3.0 | 1.030 | 1.030 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.0032 | 2881.5 | 2773.8 | 517.3 | -2.49 | 1.030 | 1.040 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.01 | 2932.8 | 2773.8 | 517.3 | -2.0 | 1.050 | 1.060 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.032 | 2619.5 | 2773.8 | 517.3 | -1.49 | 0.953 | 0.944 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.1 | 2198.3 | 2773.8 | 517.3 | -1.0 | 0.817 | 0.793 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.32 | 1670.0 | 2773.8 | 517.3 | -0.495 | 0.622 | 0.602 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 1.0 | 1244.3 | 2773.8 | 517.3 | 0.0 | 0.437 | 0.449 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 3.2 | 814.0 | 2773.8 | 517.3 | 0.505 | 0.206 | 0.293 | 2.423 | HCC70 GDC0980 0 3 72 |