Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | PIK-93 | 1 | 72 | 0.0032 | 11204.3 | 11752.8 | 1742.8 | -2.49 | 0.966 | 0.953 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.01 | 11234.5 | 11752.8 | 1742.8 | -2.0 | 0.968 | 0.956 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.032 | 11478.5 | 11752.8 | 1742.8 | -1.49 | 0.983 | 0.977 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.1 | 11468.5 | 11752.8 | 1742.8 | -1.0 | 0.982 | 0.976 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 0.32 | 11233.8 | 11752.8 | 1742.8 | -0.495 | 0.967 | 0.956 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 1.0 | 10760.3 | 11752.8 | 1742.8 | 0.0 | 0.937 | 0.916 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | PIK-93 | 1 | 72 | 3.2 | 9528.0 | 11752.8 | 1742.8 | 0.505 | 0.853 | 0.811 | 2.753 | HCC1806 PIK93 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.001 | 9616.0 | 12104.5 | 1742.8 | -3.0 | 0.842 | 0.794 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.0032 | 9333.0 | 12104.5 | 1742.8 | -2.49 | 0.822 | 0.771 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.01 | 9275.5 | 12104.5 | 1742.8 | -2.0 | 0.818 | 0.766 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.032 | 9181.8 | 12104.5 | 1742.8 | -1.49 | 0.812 | 0.759 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.1 | 9292.5 | 12104.5 | 1742.8 | -1.0 | 0.820 | 0.768 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 0.32 | 8965.0 | 12104.5 | 1742.8 | -0.495 | 0.796 | 0.741 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 1.0 | 9238.3 | 12104.5 | 1742.8 | 0.0 | 0.816 | 0.763 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | Sirolimus | 1 | 72 | 3.2 | 8674.0 | 12104.5 | 1742.8 | 0.505 | 0.775 | 0.717 | 2.796 | HCC1806 Rapamycin 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.001 | 11092.3 | 11158.5 | 1742.8 | -3.0 | 0.996 | 0.994 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.0032 | 11187.8 | 11158.5 | 1742.8 | -2.49 | 1.000 | 1.000 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.01 | 11230.5 | 11158.5 | 1742.8 | -2.0 | 1.000 | 1.010 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.032 | 11433.8 | 11158.5 | 1742.8 | -1.49 | 1.020 | 1.020 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.1 | 11446.3 | 11158.5 | 1742.8 | -1.0 | 1.020 | 1.030 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.32 | 11531.3 | 11158.5 | 1742.8 | -0.495 | 1.020 | 1.030 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 1.0 | 11205.8 | 11158.5 | 1742.8 | 0.0 | 1.000 | 1.000 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 3.2 | 11540.3 | 11158.5 | 1742.8 | 0.505 | 1.030 | 1.030 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 0.001 | 11438.8 | 11764.8 | 1742.8 | -3.0 | 0.980 | 0.972 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 0.0032 | 11138.3 | 11764.8 | 1742.8 | -2.49 | 0.961 | 0.947 | 2.755 | HCC1806 Torin1 0 1 72 |