Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Torin1 | 1 | 72 | 0.01 | 9981.5 | 11764.8 | 1742.8 | -2.0 | 0.884 | 0.848 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 0.032 | 8862.3 | 11764.8 | 1742.8 | -1.49 | 0.805 | 0.753 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 0.1 | 6527.8 | 11764.8 | 1742.8 | -1.0 | 0.615 | 0.555 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 0.32 | 5149.3 | 11764.8 | 1742.8 | -0.495 | 0.482 | 0.438 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 1.0 | 4599.5 | 11764.8 | 1742.8 | 0.0 | 0.422 | 0.391 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin1 | 1 | 72 | 3.2 | 3197.0 | 11764.8 | 1742.8 | 0.505 | 0.246 | 0.272 | 2.755 | HCC1806 Torin1 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.001 | 11442.3 | 11795.0 | 1742.8 | -3.0 | 0.978 | 0.970 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.0032 | 11163.3 | 11795.0 | 1742.8 | -2.49 | 0.960 | 0.946 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.01 | 9689.3 | 11795.0 | 1742.8 | -2.0 | 0.862 | 0.821 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.032 | 7731.3 | 11795.0 | 1742.8 | -1.49 | 0.716 | 0.655 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.1 | 3607.0 | 11795.0 | 1742.8 | -1.0 | 0.302 | 0.306 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 0.32 | 1227.5 | 11795.0 | 1742.8 | -0.495 | -0.119 | 0.104 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 1.0 | 999.5 | 11795.0 | 1742.8 | 0.0 | -0.183 | 0.085 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Torin2 | 1 | 72 | 3.2 | 931.5 | 11795.0 | 1742.8 | 0.505 | -0.203 | 0.079 | 2.759 | HCC1806 Torin2 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.001 | 11633.3 | 11736.5 | 1742.8 | -3.0 | 0.994 | 0.991 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.0032 | 10675.8 | 11736.5 | 1742.8 | -2.49 | 0.932 | 0.910 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.01 | 10202.5 | 11736.5 | 1742.8 | -2.0 | 0.901 | 0.869 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.032 | 9495.0 | 11736.5 | 1742.8 | -1.49 | 0.852 | 0.809 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.1 | 9344.3 | 11736.5 | 1742.8 | -1.0 | 0.841 | 0.796 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.32 | 8807.3 | 11736.5 | 1742.8 | -0.495 | 0.802 | 0.750 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 1.0 | 8710.3 | 11736.5 | 1742.8 | 0.0 | 0.795 | 0.742 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 3.2 | 8956.8 | 11736.5 | 1742.8 | 0.505 | 0.813 | 0.763 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.001 | 11365.0 | 12050.8 | 1742.8 | -3.0 | 0.958 | 0.943 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.0032 | 11072.0 | 12050.8 | 1742.8 | -2.49 | 0.940 | 0.919 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.01 | 10352.8 | 12050.8 | 1742.8 | -2.0 | 0.894 | 0.859 | 2.790 | HCC1806 WYE125132 0 1 72 |