Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Buparlisib | 3 | 72 | 1.0 | 1355.8 | 2804.3 | 517.3 | 0.0 | 0.485 | 0.483 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 3.2 | 341.8 | 2804.3 | 517.3 | 0.505 | -0.156 | 0.122 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 0.001 | 2803.3 | 2856.5 | 517.3 | -3.0 | 0.985 | 0.981 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 0.0032 | 3057.0 | 2856.5 | 517.3 | -2.49 | 1.060 | 1.070 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 0.01 | 2933.5 | 2856.5 | 517.3 | -2.0 | 1.020 | 1.030 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 0.032 | 3057.0 | 2856.5 | 517.3 | -1.49 | 1.060 | 1.070 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 0.1 | 2906.5 | 2856.5 | 517.3 | -1.0 | 1.010 | 1.020 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 0.32 | 2948.5 | 2856.5 | 517.3 | -0.495 | 1.030 | 1.030 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 1.0 | 2007.8 | 2856.5 | 517.3 | 0.0 | 0.733 | 0.703 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | BX-912 | 3 | 72 | 3.2 | 767.5 | 2856.5 | 517.3 | 0.505 | 0.174 | 0.269 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.001 | 2495.8 | 2855.8 | 517.3 | -3.0 | 0.894 | 0.874 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.0032 | 2887.5 | 2855.8 | 517.3 | -2.49 | 1.010 | 1.010 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.01 | 2855.3 | 2855.8 | 517.3 | -2.0 | 1.000 | 1.000 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.032 | 2725.3 | 2855.8 | 517.3 | -1.49 | 0.962 | 0.954 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.1 | 2886.0 | 2855.8 | 517.3 | -1.0 | 1.010 | 1.010 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.32 | 2810.5 | 2855.8 | 517.3 | -0.495 | 0.987 | 0.984 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 1.0 | 2748.3 | 2855.8 | 517.3 | 0.0 | 0.969 | 0.962 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 3.2 | 2384.0 | 2855.8 | 517.3 | 0.505 | 0.859 | 0.835 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.001 | 2942.3 | 2946.5 | 517.3 | -3.0 | 0.999 | 0.999 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.0032 | 3109.5 | 2946.5 | 517.3 | -2.49 | 1.040 | 1.060 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.01 | 3008.5 | 2946.5 | 517.3 | -2.0 | 1.020 | 1.020 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.032 | 3027.3 | 2946.5 | 517.3 | -1.49 | 1.020 | 1.030 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.1 | 2909.3 | 2946.5 | 517.3 | -1.0 | 0.990 | 0.987 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.32 | 2922.3 | 2946.5 | 517.3 | -0.495 | 0.993 | 0.992 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 1.0 | 2611.3 | 2946.5 | 517.3 | 0.0 | 0.906 | 0.886 | 2.510 | HCC70 CAL101 0 3 72 |