Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Omipalisib | 3 | 72 | 0.001 | 2652.0 | 2841.5 | 517.3 | -3.0 | 0.945 | 0.933 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.0032 | 2327.0 | 2841.5 | 517.3 | -2.49 | 0.844 | 0.819 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.01 | 1722.3 | 2841.5 | 517.3 | -2.0 | 0.631 | 0.606 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.032 | 856.0 | 2841.5 | 517.3 | -1.49 | 0.227 | 0.301 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.1 | 554.0 | 2841.5 | 517.3 | -1.0 | 0.028 | 0.195 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 0.32 | 379.8 | 2841.5 | 517.3 | -0.495 | -0.118 | 0.134 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 1.0 | 228.8 | 2841.5 | 517.3 | 0.0 | -0.283 | 0.081 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | Omipalisib | 3 | 72 | 3.2 | 145.0 | 2841.5 | 517.3 | 0.505 | -0.404 | 0.051 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.001 | 2855.0 | 2870.0 | 517.3 | -3.0 | 0.996 | 0.995 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.0032 | 2660.5 | 2870.0 | 517.3 | -2.49 | 0.940 | 0.927 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.01 | 2789.0 | 2870.0 | 517.3 | -2.0 | 0.977 | 0.972 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.032 | 2415.5 | 2870.0 | 517.3 | -1.49 | 0.865 | 0.842 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.1 | 2917.3 | 2870.0 | 517.3 | -1.0 | 1.010 | 1.020 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 0.32 | 2944.8 | 2870.0 | 517.3 | -0.495 | 1.020 | 1.030 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 1.0 | 2948.0 | 2870.0 | 517.3 | 0.0 | 1.020 | 1.030 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | KIN001-244 | 3 | 72 | 3.2 | 2581.3 | 2870.0 | 517.3 | 0.505 | 0.916 | 0.899 | 2.472 | HCC70 KIN001-244 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 0.001 | 2881.0 | 2689.0 | 517.3 | -3.0 | 1.060 | 1.070 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 0.0032 | 2811.3 | 2689.0 | 517.3 | -2.49 | 1.040 | 1.050 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 0.01 | 2672.0 | 2689.0 | 517.3 | -2.0 | 0.995 | 0.994 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 0.032 | 2705.8 | 2689.0 | 517.3 | -1.49 | 1.010 | 1.010 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 0.1 | 2496.8 | 2689.0 | 517.3 | -1.0 | 0.939 | 0.929 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 0.32 | 1923.8 | 2689.0 | 517.3 | -0.495 | 0.737 | 0.715 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 1.0 | 1518.3 | 2689.0 | 517.3 | 0.0 | 0.573 | 0.565 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | MK2206 | 3 | 72 | 3.2 | 1196.0 | 2689.0 | 517.3 | 0.505 | 0.423 | 0.445 | 2.378 | HCC70 MK2206 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.001 | 2860.5 | 2818.5 | 517.3 | -3.0 | 1.010 | 1.010 | 2.446 | HCC70 PI103 0 3 72 |