Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 Dactolisib 2 72
1.0
 1321.3 2310.8 722.8
0.0
 0.433 0.572 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
3.2
 1033.3 2310.8 722.8
0.505
 0.238 0.447 1.677
HCC70 BEZ235 0 2 72
HCC70 Buparlisib 2 72
0.001
 2426.5 2387.5 722.8
-3.0
 1.020 1.020 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
0.0032
 2503.0 2387.5 722.8
-2.49
 1.060 1.050 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
0.01
 2554.8 2387.5 722.8
-2.0
 1.080 1.070 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
0.032
 2538.0 2387.5 722.8
-1.49
 1.070 1.060 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
0.1
 2422.5 2387.5 722.8
-1.0
 1.020 1.010 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
0.32
 2099.0 2387.5 722.8
-0.495
 0.856 0.879 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
1.0
 1312.5 2387.5 722.8
0.0
 0.413 0.550 1.724
HCC70 BKM120 0 2 72
HCC70 Buparlisib 2 72
3.2
 418.0 2387.5 722.8
0.505
 -0.272 0.175 1.724
HCC70 BKM120 0 2 72
HCC70 BX-912 2 72
0.001
 2448.0 2337.5 722.8
-3.0
 1.060 1.050 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.0032
 2419.0 2337.5 722.8
-2.49
 1.040 1.030 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.01
 2386.3 2337.5 722.8
-2.0
 1.020 1.020 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.032
 2615.0 2337.5 722.8
-1.49
 1.140 1.120 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.1
 2469.0 2337.5 722.8
-1.0
 1.070 1.060 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.32
 2383.0 2337.5 722.8
-0.495
 1.020 1.020 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
1.0
 1866.5 2337.5 722.8
0.0
 0.751 0.799 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
3.2
 726.0 2337.5 722.8
0.505
 0.003 0.311 1.693
HCC70 BX912 0 2 72
HCC70 Alpelisib 2 72
0.001
 2178.5 2514.5 722.8
-3.0
 0.847 0.866 1.799
HCC70 BYL719 0 2 72
HCC70 Alpelisib 2 72
0.0032
 2164.8 2514.5 722.8
-2.49
 0.840 0.861 1.799
HCC70 BYL719 0 2 72
HCC70 Alpelisib 2 72
0.01
 2519.0 2514.5 722.8
-2.0
 1.000 1.000 1.799
HCC70 BYL719 0 2 72
HCC70 Alpelisib 2 72
0.032
 2342.3 2514.5 722.8
-1.49
 0.923 0.932 1.799
HCC70 BYL719 0 2 72
HCC70 Alpelisib 2 72
0.1
 2454.5 2514.5 722.8
-1.0
 0.973 0.976 1.799
HCC70 BYL719 0 2 72
HCC70 Alpelisib 2 72
0.32
 2573.5 2514.5 722.8
-0.495
 1.030 1.020 1.799
HCC70 BYL719 0 2 72
HCC70 Alpelisib 2 72
1.0
 2283.8 2514.5 722.8
0.0
 0.896 0.908 1.799
HCC70 BYL719 0 2 72