Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | Trametinib | 3 | 72 | 0.1 | 2754.8 | 3307.5 | 1180.5 | -1.0 | 0.768 | 0.833 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 0.32 | 1903.0 | 3307.5 | 1180.5 | -0.495 | 0.379 | 0.575 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 1.0 | 1567.3 | 3307.5 | 1180.5 | 0.0 | 0.210 | 0.474 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | Trametinib | 3 | 72 | 3.2 | 1419.3 | 3307.5 | 1180.5 | 0.505 | 0.132 | 0.429 | 1.486 | HCC38 Trametinib 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 0.001 | 3261.5 | 3222.8 | 1180.5 | -3.0 | 1.020 | 1.010 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 0.0032 | 3101.5 | 3222.8 | 1180.5 | -2.49 | 0.948 | 0.962 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 0.01 | 2960.8 | 3222.8 | 1180.5 | -2.0 | 0.886 | 0.919 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 0.032 | 2355.3 | 3222.8 | 1180.5 | -1.49 | 0.611 | 0.731 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 0.1 | 1751.8 | 3222.8 | 1180.5 | -1.0 | 0.313 | 0.544 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 0.32 | 1313.8 | 3222.8 | 1180.5 | -0.495 | 0.077 | 0.408 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 1.0 | 1255.8 | 3222.8 | 1180.5 | 0.0 | 0.044 | 0.390 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | WYE-125132 | 3 | 72 | 3.2 | 1143.8 | 3222.8 | 1180.5 | 0.505 | -0.022 | 0.355 | 1.449 | HCC38 WYE125132 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.001 | 3159.8 | 3159.8 | 1180.5 | -3.0 | 1.000 | 1.000 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.0032 | 3240.0 | 3159.8 | 1180.5 | -2.49 | 1.040 | 1.030 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.01 | 3242.0 | 3159.8 | 1180.5 | -2.0 | 1.040 | 1.030 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.032 | 3143.5 | 3159.8 | 1180.5 | -1.49 | 0.993 | 0.995 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.1 | 3099.8 | 3159.8 | 1180.5 | -1.0 | 0.973 | 0.981 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 0.32 | 2967.0 | 3159.8 | 1180.5 | -0.495 | 0.913 | 0.939 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 1.0 | 3028.8 | 3159.8 | 1180.5 | 0.0 | 0.941 | 0.959 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | XL147 | 3 | 72 | 3.2 | 2958.5 | 3159.8 | 1180.5 | 0.505 | 0.909 | 0.936 | 1.420 | HCC38 XL147 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.001 | 3261.0 | 3243.8 | 1180.5 | -3.0 | 1.010 | 1.010 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.0032 | 3145.5 | 3243.8 | 1180.5 | -2.49 | 0.958 | 0.970 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.01 | 3256.5 | 3243.8 | 1180.5 | -2.0 | 1.010 | 1.000 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.032 | 3190.8 | 3243.8 | 1180.5 | -1.49 | 0.978 | 0.984 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.1 | 2993.0 | 3243.8 | 1180.5 | -1.0 | 0.893 | 0.923 | 1.458 | HCC38 ZSTK474 0 3 72 |