Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 Alpelisib 2 72
3.2
 1974.0 2514.5 722.8
0.505
 0.748 0.785 1.799
HCC70 BYL719 0 2 72
HCC70 CAL-101 2 72
0.001
 2489.8 2411.0 722.8
-3.0
 1.040 1.030 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
0.0032
 2413.0 2411.0 722.8
-2.49
 1.000 1.000 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
0.01
 2513.5 2411.0 722.8
-2.0
 1.050 1.040 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
0.032
 2506.5 2411.0 722.8
-1.49
 1.050 1.040 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
0.1
 2401.0 2411.0 722.8
-1.0
 0.995 0.996 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
0.32
 2385.8 2411.0 722.8
-0.495
 0.988 0.990 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
1.0
 1993.5 2411.0 722.8
0.0
 0.793 0.827 1.738
HCC70 CAL101 0 2 72
HCC70 CAL-101 2 72
3.2
 1670.8 2411.0 722.8
0.505
 0.620 0.693 1.738
HCC70 CAL101 0 2 72
HCC70 Everolimus 2 72
0.001
 1933.0 2397.8 722.8
-3.0
 0.766 0.806 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
0.0032
 1925.8 2397.8 722.8
-2.49
 0.762 0.803 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
0.01
 2085.3 2397.8 722.8
-2.0
 0.845 0.870 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
0.032
 1952.8 2397.8 722.8
-1.49
 0.776 0.814 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
0.1
 1971.8 2397.8 722.8
-1.0
 0.786 0.822 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
0.32
 1894.3 2397.8 722.8
-0.495
 0.745 0.790 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
1.0
 1950.3 2397.8 722.8
0.0
 0.775 0.813 1.730
HCC70 Everolimus 0 2 72
HCC70 Everolimus 2 72
3.2
 1762.5 2397.8 722.8
0.505
 0.674 0.735 1.730
HCC70 Everolimus 0 2 72
HCC70 Pictilisib 2 72
0.001
 2198.5 2487.3 722.8
-3.0
 0.866 0.884 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
0.0032
 2541.0 2487.3 722.8
-2.49
 1.020 1.020 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
0.01
 2561.3 2487.3 722.8
-2.0
 1.030 1.030 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
0.032
 2442.5 2487.3 722.8
-1.49
 0.980 0.982 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
0.1
 2392.8 2487.3 722.8
-1.0
 0.957 0.962 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
0.32
 1967.0 2487.3 722.8
-0.495
 0.753 0.791 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
1.0
 1383.5 2487.3 722.8
0.0
 0.439 0.556 1.783
HCC70 GDC0941 0 2 72
HCC70 Pictilisib 2 72
3.2
 890.3 2487.3 722.8
0.505
 0.124 0.358 1.783
HCC70 GDC0941 0 2 72