Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 AS605240 2 72
0.32
 2027.3 2466.3 722.8
-0.495
 0.790 0.822 1.771
HCC70 AS605240 0 2 72
HCC70 AS605240 2 72
1.0
 1856.0 2466.3 722.8
0.0
 0.703 0.753 1.771
HCC70 AS605240 0 2 72
HCC70 AS605240 2 72
3.2
 1585.8 2466.3 722.8
0.505
 0.558 0.643 1.771
HCC70 AS605240 0 2 72
HCC70 AZD-6482 2 72
0.001
 2211.0 2468.8 722.8
-3.0
 0.879 0.896 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
0.0032
 2228.5 2468.8 722.8
-2.49
 0.888 0.903 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
0.01
 2103.8 2468.8 722.8
-2.0
 0.827 0.852 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
0.032
 1885.8 2468.8 722.8
-1.49
 0.718 0.764 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
0.1
 1580.5 2468.8 722.8
-1.0
 0.555 0.640 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
0.32
 1476.5 2468.8 722.8
-0.495
 0.496 0.598 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
1.0
 1284.5 2468.8 722.8
0.0
 0.383 0.520 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD-6482 2 72
3.2
 1082.3 2468.8 722.8
0.505
 0.256 0.438 1.772
HCC70 AZD6482 0 2 72
HCC70 AZD8055 2 72
0.001
 2323.8 2388.0 722.8
-3.0
 0.969 0.973 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
0.0032
 2281.5 2388.0 722.8
-2.49
 0.948 0.955 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
0.01
 2068.0 2388.0 722.8
-2.0
 0.840 0.866 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
0.032
 1769.0 2388.0 722.8
-1.49
 0.681 0.741 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
0.1
 1587.3 2388.0 722.8
-1.0
 0.578 0.665 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
0.32
 1355.0 2388.0 722.8
-0.495
 0.440 0.567 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
1.0
 1300.0 2388.0 722.8
0.0
 0.406 0.544 1.724
HCC70 AZD8055 0 2 72
HCC70 AZD8055 2 72
3.2
 1297.3 2388.0 722.8
0.505
 0.404 0.543 1.724
HCC70 AZD8055 0 2 72
HCC70 Dactolisib 2 72
0.001
 2350.5 2310.8 722.8
-3.0
 1.020 1.020 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.0032
 2137.3 2310.8 722.8
-2.49
 0.909 0.925 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.01
 2010.0 2310.8 722.8
-2.0
 0.840 0.870 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.032
 1708.0 2310.8 722.8
-1.49
 0.670 0.739 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.1
 1557.0 2310.8 722.8
-1.0
 0.580 0.674 1.677
HCC70 BEZ235 0 2 72
HCC70 Dactolisib 2 72
0.32
 1509.8 2310.8 722.8
-0.495
 0.552 0.653 1.677
HCC70 BEZ235 0 2 72