LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trametinib | 180614_BG_02 | 1775 | 0.0252 | 11 | 34 | 3 | 20 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_1 | 45 | 0.0247 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00473 | 0.1762 |
| Trametinib | 180614_BG_02 | 1951 | 0.0255 | 6 | 44 | 9 | 21 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_3 | 50 | 0.0250 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00499 | 0.2025 |
| Trametinib | 180614_BG_03 | 1799 | 0.0298 | 14 | 40 | 9 | 22 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_6 | 54 | 0.0291 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00915 | 0.1799 |
| Vorinostat | 180614_BG_02 | 1234 | 0.0436 | 28 | 27 | 10 | 16 | Vorinostat | 9.98 | treatment | 72 | 1 | MCF10A-GM_1 | 55 | 0.0427 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02267 | 0.0800 |
| Trametinib | 180614_BG_03 | 1792 | 0.0301 | 36 | 19 | 4 | 22 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_4 | 55 | 0.0298 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00978 | 0.1788 |
| Trametinib | 180614_BG_02 | 1751 | 0.0322 | 18 | 39 | 9 | 11 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_2 | 57 | 0.0315 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01153 | 0.1724 |
| Trametinib | 180614_BG_02 | 1792 | 0.0319 | 27 | 31 | 8 | 16 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_1 | 58 | 0.0314 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01136 | 0.1788 |
| Etoposide | 180703_BG_10 | 1749 | 0.0332 | 28 | 31 | 10 | 7 | Etoposide | 9.98 | treatment | 72 | 3 | MCF10A-GM_3 | 59 | 0.0326 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.00083 | 0.0602 |
| Trametinib | 180614_BG_02 | 1685 | 0.0366 | 35 | 28 | 4 | 17 | Trametinib | 0.099799981 | treatment | 72 | 1 | MCF10A-GM_1 | 63 | 0.0360 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01605 | 0.1619 |
| Trametinib | 180614_BG_03 | 1896 | 0.0327 | 32 | 31 | 8 | 10 | Trametinib | 0.998 | treatment | 72 | 1 | MCF10A-GM_4 | 63 | 0.0322 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01216 | 0.1945 |
| Etoposide | 180614_BG_02 | 888 | 0.0722 | 26 | 40 | 6 | 22 | Etoposide | 9.98 | treatment | 72 | 1 | MCF10A-GM_2 | 66 | 0.0692 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.04919 | -0.0003 |
| Neratinib | 180622_BG_8 | 1558 | 0.0427 | 33 | 35 | 8 | 14 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_8 | 68 | 0.0418 | 832.0 | 168.3 | 20016 | 537.9 | 0.0261 | 0.01570 | 0.1465 |
| Trametinib | 180703_BG_12 | 3489 | 0.0192 | 47 | 21 | 10 | 5 | Trametinib | 0.031603332 | treatment | 72 | 3 | MCF10A-GM_8 | 68 | 0.0191 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01268 | 0.2623 |
| Neratinib | 180703_BG_10 | 3149 | 0.0218 | 22 | 47 | 10 | 21 | Neratinib | 0.997999609 | treatment | 72 | 3 | MCF10A-GM_2 | 69 | 0.0214 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01036 | 0.2300 |
| Trametinib | 180614_BG_02 | 1807 | 0.0377 | 48 | 22 | 14 | 14 | Trametinib | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_3 | 70 | 0.0373 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01730 | 0.1811 |
| Trametinib | 180614_BG_03 | 2093 | 0.0328 | 42 | 28 | 14 | 12 | Trametinib | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_6 | 70 | 0.0324 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01237 | 0.2225 |
| Trametinib | 180703_BG_10 | 3499 | 0.0201 | 36 | 35 | 4 | 17 | Trametinib | 0.099799981 | treatment | 72 | 3 | MCF10A-GM_1 | 71 | 0.0199 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.01191 | 0.2632 |
| Vorinostat | 180614_BG_02 | 2414 | 0.0291 | 25 | 46 | 6 | 20 | Vorinostat | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_1 | 71 | 0.0286 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00858 | 0.2642 |
| Trametinib | 180614_BG_03 | 1982 | 0.0360 | 47 | 26 | 10 | 19 | Trametinib | 0.319359801 | treatment | 72 | 1 | MCF10A-GM_6 | 73 | 0.0355 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01553 | 0.2070 |
| Etoposide | 180703_BG_10 | 1668 | 0.0425 | 48 | 25 | 8 | 20 | Etoposide | 3.193598006 | treatment | 72 | 3 | MCF10A-GM_3 | 73 | 0.0419 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | 0.01013 | 0.0476 |
| Trametinib | 180703_BG_10 | 3270 | 0.0226 | 43 | 32 | 3 | 20 | Trametinib | 0.319359801 | treatment | 72 | 3 | MCF10A-GM_1 | 75 | 0.0224 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00938 | 0.2418 |
| Trametinib | 180703_BG_10 | 3116 | 0.0241 | 42 | 34 | 8 | 13 | Trametinib | 0.099799981 | treatment | 72 | 3 | MCF10A-GM_2 | 76 | 0.0238 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00799 | 0.2267 |
| Palbociclib | 180703_BG_10 | 2833 | 0.0264 | 45 | 31 | 9 | 10 | Palbociclib | 10.01326667 | treatment | 72 | 3 | MCF10A-GM_2 | 76 | 0.0261 | 1387.8 | 74.9 | 21564 | 711.9 | 0.0318 | -0.00567 | 0.1976 |
| Palbociclib | 180614_BG_02 | 1623 | 0.0456 | 42 | 34 | 9 | 10 | Palbociclib | 10.01326667 | treatment | 72 | 1 | MCF10A-GM_2 | 76 | 0.0447 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02474 | 0.1517 |
| Trametinib | 180614_BG_02 | 1937 | 0.0384 | 43 | 33 | 7 | 12 | Trametinib | 0.031603332 | treatment | 72 | 1 | MCF10A-GM_2 | 76 | 0.0378 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01776 | 0.2005 |