LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20359)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neratinib | 180614_BG_03 | 4630 | 0.0318 | 88 | 62 | 14 | 9 | Neratinib | 0.299399965 | treatment | 72 | 1 | MCF10A-GM_6 | 150 | 0.0314 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01139 | 0.4729 |
| Taxol | 180614_BG_02 | 14918 | 0.0291 | 53 | 382 | 14 | 5 | Paclitaxel | 0.000998 | treatment | 72 | 1 | MCF10A-GM_3 | 435 | 0.0283 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00834 | 0.9382 |
| Neratinib | 180614_BG_02 | 16951 | 0.0194 | 39 | 291 | 14 | 20 | Neratinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_3 | 330 | 0.0191 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00090 | 0.9972 |
| Neratinib | 180614_BG_02 | 7034 | 0.0187 | 15 | 117 | 14 | 18 | Neratinib | 0.099799997 | treatment | 72 | 1 | MCF10A-GM_3 | 132 | 0.0184 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00158 | 0.6247 |
| Neratinib | 180614_BG_03 | 1612 | 0.0523 | 51 | 36 | 14 | 13 | Neratinib | 0.997999609 | treatment | 72 | 1 | MCF10A-GM_6 | 87 | 0.0512 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.03121 | 0.1499 |
| Etoposide | 180614_BG_02 | 10157 | 0.0198 | 54 | 148 | 14 | 17 | Etoposide | 0.099799999 | treatment | 72 | 1 | MCF10A-GM_3 | 202 | 0.0195 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00050 | 0.7710 |
| Etoposide | 180614_BG_03 | 1029 | 0.0982 | 61 | 46 | 14 | 16 | Etoposide | 9.98 | treatment | 72 | 1 | MCF10A-GM_6 | 107 | 0.0942 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.07419 | 0.0349 |
| Neratinib | 180614_BG_03 | 16626 | 0.0137 | 59 | 170 | 14 | 11 | Neratinib | 0.001081167 | treatment | 72 | 1 | MCF10A-GM_6 | 229 | 0.0136 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00641 | 0.9881 |
| Dasatinib | 180614_BG_04 | 6492 | 0.0423 | 128 | 152 | 14 | 17 | Dasatinib | 0.316033316 | treatment | 72 | 1 | MCF10A-GM_9 | 280 | 0.0413 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.02135 | 0.5944 |
| Neratinib | 180614_BG_02 | 7608 | 0.0227 | 44 | 130 | 14 | 15 | Neratinib | 0.099799997 | treatment | 72 | 1 | MCF10A-GM_2 | 174 | 0.0224 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00236 | 0.6549 |
| Etoposide | 180614_BG_04 | 17213 | 0.0261 | 124 | 328 | 14 | 8 | Etoposide | 0.003326667 | treatment | 72 | 1 | MCF10A-GM_9 | 452 | 0.0256 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00559 | 1.0044 |
| Etoposide | 180614_BG_03 | 986 | 0.1017 | 86 | 23 | 14 | 4 | Etoposide | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_5 | 109 | 0.0995 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.07955 | 0.0246 |
| Alpelisib | 180614_BG_04 | 10966 | 0.0276 | 140 | 167 | 14 | 21 | Alpelisib | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_9 | 307 | 0.0272 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00724 | 0.8031 |
| Etoposide | 180614_BG_02 | 14649 | 0.0184 | 43 | 227 | 14 | 9 | Etoposide | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_3 | 270 | 0.0181 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00190 | 0.9299 |
| Etoposide | 180614_BG_03 | 1042 | 0.1357 | 100 | 55 | 14 | 17 | Etoposide | 3.193598006 | treatment | 72 | 1 | MCF10A-GM_6 | 155 | 0.1295 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.10949 | 0.0380 |
| Alpelisib | 180614_BG_04 | 17433 | 0.0197 | 108 | 238 | 14 | 4 | Alpelisib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_8 | 346 | 0.0195 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00053 | 1.0103 |
| Alpelisib | 180614_BG_04 | 16325 | 0.0255 | 114 | 305 | 14 | 10 | Alpelisib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_9 | 419 | 0.0250 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00503 | 0.9796 |
| Neratinib | 180614_BG_03 | 17016 | 0.0189 | 69 | 254 | 14 | 10 | Neratinib | 0.001081167 | treatment | 72 | 1 | MCF10A-GM_5 | 323 | 0.0186 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00137 | 0.9989 |
| Alpelisib | 180614_BG_04 | 6841 | 0.0354 | 169 | 79 | 14 | 14 | Alpelisib | 9.98 | treatment | 72 | 1 | MCF10A-GM_9 | 248 | 0.0350 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.01499 | 0.6142 |
| Alpelisib | 180614_BG_02 | 16699 | 0.0169 | 46 | 237 | 14 | 3 | Alpelisib | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_3 | 283 | 0.0167 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00333 | 0.9901 |
| Neratinib | 180614_BG_03 | 17086 | 0.0194 | 58 | 275 | 14 | 14 | Neratinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_6 | 333 | 0.0191 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00088 | 1.0009 |
| Neratinib | 180614_BG_04 | 16992 | 0.0211 | 122 | 239 | 14 | 22 | Neratinib | 0.00998 | treatment | 72 | 1 | MCF10A-GM_9 | 361 | 0.0208 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.00081 | 0.9983 |
| Alpelisib | 180614_BG_03 | 16992 | 0.0167 | 38 | 247 | 14 | 3 | Alpelisib | 0.033266667 | treatment | 72 | 1 | MCF10A-GM_6 | 285 | 0.0165 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | -0.00350 | 0.9983 |
| Taxol | 180614_BG_04 | 1548 | 0.5489 | 325 | 703 | 14 | 20 | Paclitaxel | 0.00998 | treatment | 72 | 1 | MCF10A-GM_9 | 1028 | 0.3991 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.37907 | 0.1390 |
| Taxol | 180614_BG_03 | 5421 | 0.1343 | 195 | 559 | 14 | 6 | Paclitaxel | 0.002994 | treatment | 72 | 1 | MCF10A-GM_6 | 754 | 0.1221 | 889.0 | 105.5 | 17054 | 348.0 | 0.0200 | 0.10211 | 0.5284 |