Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | AZD2014 | 0.030975176 | -0.1702 | 0.6409 | 4.3568 | -1.0000 | 0.2221 | 0.9310 | 3.11e-15 |
| MCF 10A | AZD5363 | inf | 0.6025 | 0.2092 | 0.0802 | 0.5789 | 0.3665 | 0.9389 | 6.66e-16 |
| MCF 10A | AZD6738 | 6.530884217 | 0.1820 | 0.0788 | 12.1220 | -1.0000 | 1.7763 | 0.9830 | 1.11e-16 |
| MCF 10A | BMS-265246 | 0.304944263 | 0.0710 | 0.4137 | 6.3855 | -0.7513 | 0.3016 | 0.9516 | 1.11e-16 |
| MCF 10A | Ulixertinib | 1.461707314 | 0.2159 | 0.2704 | 2.7171 | -0.1676 | 0.4662 | 0.9511 | 1.11e-16 |
| MCF 10A | Alvocidib | 0.099467899 | -0.4802 | 0.3475 | 0.1398 | -0.5288 | 2.1178 | 0.9920 | 1.11e-16 |
| MCF 10A | GSK2334470 | 127.2855112 | 0.8292 | 0.0271 | 886.4613 | -0.9671 | 0.5546 | 0.7883 | 3.72e-09 |
| MCF 10A | Ribociclib | 21.11238563 | 0.4876 | 0.1616 | 1000.0000 | -1.0000 | 0.2848 | 0.8863 | 1.58e-12 |
| MCF 10A | LY3023414 | 0.005085163 | -0.0482 | 0.7501 | 0.0163 | -0.2112 | 0.3018 | 0.9088 | 1e-13 |
| MCF 10A | RO-3306 | 5.973258525 | -0.0959 | 0.0874 | 9.3379 | -1.0000 | 2.4589 | 0.9848 | 1.11e-16 |
| MCF 10A | Rucaparib | inf | 0.8695 | 0.0527 | 79.7513 | 0.7576 | 0.2151 | 0.3749 | 0.002812424 |
| MCF 10A | Senexin B | 617.6674136 | 0.8672 | 0.0282 | 1000.0000 | -0.1291 | 0.4768 | 0.7287 | 8.28e-08 |
| MCF 10A | SHP099 | 13.33532157 | 0.6599 | 0.0155 | 20.0345 | -1.0000 | 2.6990 | 0.8458 | 7.1e-11 |
| MCF 10A | THZ1 | 0.046492791 | -0.4253 | 0.4095 | 0.1201 | -0.6388 | 0.8674 | 0.9905 | 1.11e-16 |
| MCF 10A | THZ531 | 0.403782298 | -0.4375 | 0.1475 | 0.6623 | -1.0000 | 2.2199 | 0.9948 | 1.11e-16 |
| MCF7 | MK 1775 | -inf | -0.1007 | ||||||
| MCF7 | AZD2014 | 3.5e-06 | -0.0241 | 0.8202 | 0.0000 | -0.1837 | 0.1224 | 0.6911 | 4.19e-07 |
| MCF7 | AZD5363 | 12.4103884 | 0.4782 | 0.2060 | 1.1629 | 0.3135 | 0.4165 | 0.8201 | 4.86e-10 |
| MCF7 | AZD6738 | 3.087754601 | 0.0508 | 0.1795 | 12.4507 | -1.0000 | 0.7879 | 0.9144 | 4.54e-14 |
| MCF7 | BMS-265246 | 0.007863864 | 0.0723 | 0.6940 | 0.0070 | 0.0264 | 0.4576 | 0.9598 | 1.11e-16 |
| MCF7 | Ulixertinib | 3.786667089 | 0.3222 | 0.1986 | 9.6095 | -0.2846 | 0.4838 | 0.8626 | 1.69e-11 |
| MCF7 | Alvocidib | -inf | -0.2526 | ||||||
| MCF7 | GSK2334470 | 3.397326315 | 0.2955 | 0.2507 | 120.0410 | -1.0000 | 0.3082 | 0.7269 | 9e-08 |
| MCF7 | Ribociclib | 0.189284804 | 0.2285 | 0.4067 | 0.0345 | 0.2453 | 0.3959 | 0.8429 | 8.95e-11 |
| MCF7 | LY3023414 | 4.48e-05 | -0.3005 | 0.8320 | 2.0083 | -0.9593 | 0.1000 | 0.7407 | 4.7e-08 |