Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Ribociclib | 2.691890869 | 0.3645 | 0.3425 | 1000.0000 | -0.7904 | 0.1602 | 0.9056 | 1.53e-13 |
| Hs 578T | LY3023414 | 0.000331352 | 0.0271 | 0.6875 | 0.1184 | -0.4001 | 0.1000 | 0.8522 | 4.17e-11 |
| Hs 578T | RO-3306 | 4.300129294 | -0.0976 | 0.1258 | 9.7624 | -1.0000 | 1.3399 | 0.9749 | 1.11e-16 |
| Hs 578T | Rucaparib | 478.5688189 | 0.6723 | 0.1013 | 1000.0000 | -0.1130 | 0.2766 | 0.5974 | 1.15e-05 |
| Hs 578T | Senexin B | 2420179.078 | 0.7716 | 0.1355 | 1000.0000 | 0.3393 | 0.1457 | 0.6302 | 3.97e-06 |
| Hs 578T | SHP099 | 222.1051901 | 0.5953 | 0.1451 | 1000.0000 | -0.2087 | 0.2319 | 0.7318 | 7.17e-08 |
| Hs 578T | THZ1 | 0.018250125 | -0.4195 | 0.5223 | 0.0232 | -0.3000 | 1.9491 | 0.9905 | 1.11e-16 |
| Hs 578T | THZ531 | 0.048528081 | -0.2670 | 0.3750 | 0.0565 | -0.2217 | 2.4067 | 0.9945 | 1.11e-16 |
| HME1 | MK 1775 | 0.311734421 | -0.1519 | 0.4391 | 7.7966 | -1.0000 | 0.3413 | 0.9413 | 4.44e-16 |
| HME1 | AZD2014 | 0.017460717 | 0.1122 | 0.5969 | 0.3948 | -0.3458 | 0.1686 | 0.9585 | 1.11e-16 |
| HME1 | AZD5363 | 28.44450868 | 0.5695 | 0.1924 | 1000.0000 | -0.6875 | 0.2430 | 0.8264 | 3.11e-10 |
| HME1 | AZD6738 | 5.825895792 | 0.2920 | 0.0055 | 4.9604 | 0.2763 | 5.0000 | 0.8741 | 5.61e-12 |
| HME1 | BMS-265246 | 0.001224504 | 0.0652 | 0.8579 | 0.0014 | -0.0301 | 0.4949 | 0.9271 | 6.11e-15 |
| HME1 | Ulixertinib | 0.212403292 | -0.0098 | 0.4485 | 0.3361 | -0.1385 | 0.5327 | 0.9448 | 2.22e-16 |
| HME1 | Alvocidib | 0.114196744 | -0.3549 | 0.3125 | 0.4526 | -1.0000 | 0.7978 | 0.9854 | 1.11e-16 |
| HME1 | GSK2334470 | 136.3428366 | 0.6784 | 0.1302 | 969.9423 | -0.3383 | 0.2634 | 0.5582 | 3.68e-05 |
| HME1 | Ribociclib | 1.226062584 | 0.2866 | 0.3557 | 348.8011 | -1.0000 | 0.1944 | 0.9022 | 2.38e-13 |
| HME1 | LY3023414 | 0.00281434 | 0.0335 | 0.6767 | 41.9336 | -1.0000 | 0.1143 | 0.9275 | 5.66e-15 |
| HME1 | RO-3306 | 4.087843972 | -0.0172 | 0.0517 | 4.0640 | 0.0144 | 5.0000 | 0.9574 | 1.11e-16 |
| HME1 | Rucaparib | inf | 0.7189 | 0.1295 | 1000.0000 | 0.4363 | 0.1448 | 0.3705 | 0.003075156 |
| HME1 | Senexin B | inf | 0.7841 | 0.1891 | 0.0158 | 0.7123 | 0.2814 | 0.4068 | 0.001463753 |
| HME1 | SHP099 | 16.29543423 | 0.6344 | 0.0890 | 71.5373 | -1.0000 | 0.7426 | 0.7358 | 5.94e-08 |
| HME1 | THZ1 | -inf | -0.3007 | ||||||
| HME1 | THZ531 | 0.22121156 | -0.1882 | 0.1768 | 0.2567 | -0.2330 | 2.5689 | 0.9759 | 1.11e-16 |
| MCF 10A | MK 1775 | 4.928502071 | -0.1207 | 0.1367 | 9.4221 | -1.0000 | 1.6953 | 0.9500 | 1.11e-16 |